1075-00-9

Basic information

• Product Name: 8-Fluoroisoquinoline
• Synonyms: 8-Fluoroisoquinoline;8-Fluoro-2-azanaphthalene
• CAS NO: 1075-00-9
• Molecular Formula: C₉H₆FN
• Molecular Weight: 147.15
• Product Categories: blocks;FluoroCompounds;Quinolines;Heterocyclic Series
• Mol File: 1075-00-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 255.3°Cat760mmHg
• Flash Point: 108.2°C
• Appearance: /
• Density: 1.216g/cm³
• Vapor Pressure: 0.0264mmHg at 25°C
• Refractive Index: 1.614
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.82±0.23(Predicted)
• CAS DataBase Reference: 8-Fluoroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Fluoroisoquinoline(1075-00-9)
• EPA Substance Registry System: 8-Fluoroisoquinoline(1075-00-9)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 1075-00-9(Hazardous Substances Data)

Usage

General Description

8-Fluoroisoquinoline is a synthetic, organic compound that falls under the isoquinoline group of chemicals. It is characterized by the presence of a fluorine atom at the 8th position of the isoquinoline structure. It is used in various applications due to its unique properties and structure, but primarily in research as a building block for complex chemical syntheses. It can be used in developing pharmaceuticals, such as antitumor and antiviral agents, as well as in the creation of functional materials. Its exact properties such as melting point, boiling point, or solubility can vary based on any additional functional groups that may be attached to its core structure.

InChI:InChI=1/C9H6FN/c10-9-3-1-2-7-4-5-11-6-8(7)9/h1-6H

Upstream product

• 446-52-6 2-Fluorobenzaldehyde 
• 608515-45-3 2-fluoro-6-(2-(trimethylsilyl)ethynyl)benzaldehyde 
• 1404367-16-3 N-(2,2-dimethoxyethyl)-N-(2-fluorobenzyl)-4-methylbenzenesulfonamide 
• 1178920-49-4 N-(2-fluorobenzyl)-2,2-dimethoxyethanamine 
• 444898-80-0 (2-fluorobenzylidene)(2,2-dimethoxyethyl)amine 

Downstream Products

• 444898-84-4 8-fluoro-2H-isoquinolin-1-one 
• 1159997-87-1 2-benzyl-8-fluoroisoquinolinium bromide 
• 1404367-17-4 4-bromo-8-fluoroisoquinoline 
• 123594-01-4 8-fluoro-1,2,3,4-tetrahydroisoquinoline 
• 1159997-88-2 2-benzyl-8-fluoro-1-(4-(trifluoromethyl)phenyl)-1,2-dihydroisoquinoline 

Relevant articles and documents

SUBSTITUTED ARYLMETHYLUREAS AND HETEROARYLMETHYLUREAS, ANALOGUES THEREOF, AND METHODS USING SAME

The present invention includes substituted arylmethyl ureas and heteroarylmethyl-ureas, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infections in a patient.

ALDOSTERONE SYNTHASE INHIBITORS

This invention relates to tricyclic triazole analogues of the formula I or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthetase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthetase.

Synthesis of novel substituted isoquinolones

A series of novel substituted isoquinolones have been synthesised. This has been achieved by two routes, either Curtius rearrangment of cinnamic acids or via an isoquinoline N-oxide.