1075-14-5

Basic information

• Product Name: THIOCOUMARIN
• Synonyms: THIOCOUMARIN;2H-1-Benzothiopyran-2-one;Thiacoumarin
• CAS NO: 1075-14-5
• Molecular Formula: C₉H₆OS
• Molecular Weight: 162.21
• Mol File: 1075-14-5.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: THIOCOUMARIN(CAS DataBase Reference)
• NIST Chemistry Reference: THIOCOUMARIN(1075-14-5)
• EPA Substance Registry System: THIOCOUMARIN(1075-14-5)

Safety Data

• Hazardous Substances Data: 1075-14-5(Hazardous Substances Data)

Upstream product

• 1664-63-7 2-amino-cinnamic acid 
• 108-98-5 thiophenol 
• 81536-21-2 ethyl 2-mercaptodihydrocinnamate 
• 81536-24-5 trans-3-(2-mercaptophenyl)-2-propenoic acid ethyl ester 
• 70030-52-3 (E)-S-phenyl 3-phenylprop-2-enethioate 
• 7664-93-9 sulfuric acid 
• 81536-29-0 2-mercaptocinnamic acid 
• 5962-02-7 Dihydro-3,4 thio-1 coumarine 
• 254-37-5 2H-thiochromene 
• 108-24-7 acetic anhydride 
• 102-92-1 Cinnamoyl chloride 
• 140-10-3 (E)-3-phenylacrylic acid 

Relevant articles and documents

A stereoselective synthetic route to (E)-α,β-unsaturated thioesters

Terminal alkynes 1 react with Cp2Zr(H)Cl (Cp = η5-C5H5) and CO to give acylzirconocene chloride derivatives 2, which are trapped with arylsulfenyl chlorides to afford (E)-α,β-unsaturated thioesters.

CARBONIC ANHYDRASE INHIBITORS WITH ANTIMETASTATIC ACTIVITY

Compositions for the treatment of cancer comprising coumarin and thiocoumarin derivatives of Formulas I- XII are disclosed. Said derivatives preferentially inhibit carbonic anhydrase IX and XII (which are associated with hypoxic and metastatic tumours) over inhibiting carbonic anhydrase I and II activity. The compositions therefore are suited for treatment of hypoxic or metastatic cancers due to this selective mechanism of action.

Biotransformation of Unsaturated Heterocyclic Rings by Pseudomonas putida to Yield cis-Diols

New cis-diols metabolites of both aromatic and non-aromatic heterocyclic rings have been isolated from growing cultures of a mutant strain of the soil bacterium Pseudomonas putida (UV4) and stereochemically assigned; a novel heterocyclic cis-diol of benzothiophene, 2,3-dihydroxy-2,3-dihydrobenzothiophene is found to exist exclusively in the cis-configuration in water but equilibrates readily with the trans-isomer.