1075-20-3Relevant articles and documents
A New and Mild System for the Generation of Nonstabilized Carbonyl Ylides: Synthetically Practical Use in Reactions with Electron-Deficient Dipolarophiles
Hojo, Makoto,Aihara, Hidenori,Suginohara, Yoshifusa,Sakata, Kyosuke,Nakamura, Shin-ya
, p. 8610 - 8611 (1997)
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Selective lewis acid catalyzed assembly of phosphonomethyl ethers: Three-step synthesis of tenofovir
Ocampo, Charles E.,Lee, Doris,Jamison, Timothy F.
supporting information, p. 820 - 823 (2015/03/18)
Described herein is a novel Lewis acid catalyzed rearrangement-coupling of oxygen heterocycles and bis(diethylamino)chlorophosphine that provides direct formation of the phosphonomethyl ether functionality found in several important antiretroviral agents. A wide range of dioxolanes and 1,3-dioxanes may be employed, furnishing the desired products in good yield. The utility of this method is demonstrated in a novel synthesis of tenofovir, an antiretroviral drug used in the treatment of HIV/AIDS and hepatitis B.
A new and more efficient synthesis of methylene acetals
Chu, Guobiao,Zhang, Yanqiao,Li, Chunbao,Zhang, Yuqing
experimental part, p. 3828 - 3832 (2010/03/03)
A new and efficient synthesis of benzyl chlorides and methylene acetals by use of 2,4-dichloro-6-methoxy[l,3,5]triazine (MeOTCT) and dimethyl sulfoxide has been developed. Chlorides are the major products for benzyl alcohols, while methylene acetals are the major products for secondary alcohols. This procedure provides the highest yields so far for methylene acetals of steroids. A plausible mechanism is proposed on the basis of the experiments. Georg Thieme Verlag Stuttgart.
