1076225-27-8 Usage
Description
4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile, also known as PF-998425, is a novel, nonsteroidal androgen receptor antagonist with potential applications in the pharmaceutical and cosmetic industries. Its unique chemical structure allows it to interact with androgen receptors, making it a promising candidate for various therapeutic and cosmetic applications.
Uses
Used in Pharmaceutical Industry:
4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile is used as a sebum control agent for the treatment of androgenetic alopecia. Its ability to act as an androgen receptor antagonist helps in reducing sebum production, which is a common cause of hair loss in individuals with androgenetic alopecia.
Used in Cosmetic Industry:
In the cosmetic industry, 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile is used as an active ingredient in anti-acne and anti-aging products. Its sebum control properties make it an effective treatment for acne-prone skin, while its potential to modulate androgen receptors may contribute to anti-aging effects by reducing the signs of skin aging related to hormonal imbalances.
Check Digit Verification of cas no
The CAS Registry Mumber 1076225-27-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,7,6,2,2 and 5 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1076225-27:
(9*1)+(8*0)+(7*7)+(6*6)+(5*2)+(4*2)+(3*5)+(2*2)+(1*7)=138
138 % 10 = 8
So 1076225-27-8 is a valid CAS Registry Number.
1076225-27-8Relevant articles and documents
Kinetic resolution of secondary alcohols catalyzed by chiral phosphoric acids
Harada, Shingo,Kuwano, Satoru,Yamaoka, Yousuke,Yamada, Ken-Ichi,Takasu, Kiyosei
supporting information, p. 10227 - 10230 (2013/10/21)
Acid instead of base: Kinetic resolution of secondary alcohols is realized using chiral Bronsted acid catalyzed acylation instead of the conventional basic conditions. A broad range of functional groups are tolerated, such as aldehydes, carboxylic acids, and enoates. The selectivity factor (s) reaches up to 215 at ambient temperature. Copyright
