107754-20-1

Basic information

• Product Name: 4-[[5-[[cyclopentyloxy)carbonyl]amino]-1-methylindol-3-yl]methyl]-3-methoxybenzoic acid
• Synonyms: Benzoic acid, 4-[[5-[[(cyclopentyloxy)carbonyl]aMino]-1-Methyl-1H-indol-3-yl]Methyl]-3-Methoxy-;4-[[5-[[cyclopentyloxy)carbonyl]amino]-1-methylindol-3-yl]methyl]-3-methoxybenzoic acid
• CAS NO: 107754-20-1
• Molecular Formula: C₂₄H₂₆N₂O₅
• Molecular Weight: 422.47364
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;API;Aromatics;Heterocycles;Intermediates
• Mol File: 107754-20-1.mol
• Article Data: 9

Chemical Properties

• Melting Point: 203-209?C (dec.)
• Boiling Point: 601.4°C at 760 mmHg
• Flash Point: 317.5°C
• Appearance: /
• Density: 1.3g/cm³
• Vapor Pressure: 2.58E-15mmHg at 25°C
• Refractive Index: 1.629
• Storage Temp.: Refrigerator
• CAS DataBase Reference: 4-[[5-[[cyclopentyloxy)carbonyl]amino]-1-methylindol-3-yl]methyl]-3-methoxybenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[[5-[[cyclopentyloxy)carbonyl]amino]-1-methylindol-3-yl]methyl]-3-methoxybenzoic acid(107754-20-1)
• EPA Substance Registry System: 4-[[5-[[cyclopentyloxy)carbonyl]amino]-1-methylindol-3-yl]methyl]-3-methoxybenzoic acid(107754-20-1)

Safety Data

• Hazardous Substances Data: 107754-20-1(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

An intermediate of Zafirlukast (Z125000), as leukotriene antagonist.

InChI:InChI=1/C24H26N2O5/c1-26-14-17(11-15-7-8-16(23(27)28)12-22(15)30-2)20-13-18(9-10-21(20)26)25-24(29)31-19-5-3-4-6-19/h7-10,12-14,19H,3-6,11H2,1-2H3,(H,25,29)(H,27,28)

Upstream product

• 3556-83-0 methyl 4-methyl-3-methoxybenzoate 
• 29906-67-0 1-methyl-5-nitro-1H-indole 
• 7151-68-0 3-methoxy-p-toluic acid 
• 107754-15-4 3-methoxy-4-(1-methyl-5-nitroindol-3-ylmethyl)-benzoic acid methyl ester 
• 107786-36-7 4-[5-nitro-1H-indol-3-ylmethyl]-3-methoxy-benzoic acid methylester 
• 107754-14-3 methyl 4-<(5-amino-1-methylindol-3-yl)methyl>-3-methoxybenzoate 
• 70264-94-7 methyl 4-(bromomethyl)-3-methoxybenzoate 
• 50715-28-1 cyclopentyl chloroformate 
• 6146-52-7 5-nitroindole 
• 107754-19-8 methyl 4-[5-(cyclopentyloxycarbonyl)amino-1-methyl-indol-3-ylmethyl]-3-methoxybenzoate 

Downstream Products

• 107753-78-6 ZAFIRLUKAST 

Relevant articles and documents

Dual Farnesoid X Receptor/Soluble Epoxide Hydrolase Modulators Derived from Zafirlukast

The nuclear farnesoid X receptor (FXR) and the enzyme soluble epoxide hydrolase (sEH) are validated molecular targets to treat metabolic disorders such as non-alcoholic steatohepatitis (NASH). Their simultaneous modulation in vivo has demonstrated a triad of anti-NASH effects and thus may generate synergistic efficacy. Here we report dual FXR activators/sEH inhibitors derived from the anti-asthma drug Zafirlukast. Systematic structural optimization of the scaffold has produced favorable dual potency on FXR and sEH while depleting the original cysteinyl leukotriene receptor antagonism of the lead drug. The resulting polypharmacological activity profile holds promise in the treatment of liver-related metabolic diseases.

An improved and scalable process for zafirlukast: An asthma drug

An improved and scalable process for the large-scale production of zafirlukast (Accolate), an important drug for asthma, is discussed along with impurity and scale-up-related issues.

PROCESSES FOR PREPARING ZAFIRLUKAST

An improved process for the preparation of substantially pure zafirlukast and pharmaceutical compositions thereof.