107841-22-5Relevant articles and documents
CINNOLINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS
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Page/Page column 49-50, (2010/11/28)
The present invention is directed to certain cinnoline compounds of formula (I) that are PDE10 inhibitors, pharmaceutical compositions containing such compounds and process for preparing such compounds. The invention is also directed to methods of treating diseases treatable by modulation of PDE10 enzyme, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
SYNTHESIS OF RIGID DOPAMINE CONGENERS: CIS AND TRANS 2-(p-METHOXYPHENYL)-3-METHYLMORPHOLINE
Bettoni, Giancarlo,Cellucci, Carla,Ferorelli, Savina,Perrone, Roberto,Tortorella, Vincenzo
, p. 2117 - 2120 (2007/10/02)
A synthetic pathway is reported for the preparation of cis and trans forms of 2-(p-methoxyphenyl)-3-methyl-morpholine from the same key-compound, the p-methoxy- -(N,N'-dibenzylamino)-propiophenone, through stereospecific reduction processes.