107866-78-4Relevant articles and documents
CONDENSATION REACTIONS BETWEEN AROMATIC ALDEHYDES AND SOME HETEROCYCLIC AROMATIC AMINES
Forlani, Luciano,Sintoni, Marina,Todesco, Paolo E.
, p. 229 - 232 (2007/10/02)
1,1-Diamino derivatives are obtained by means of reactions between 2-aminothiazole and aromatic aldehydes carried out in methanol (and in dimethyl sulphoxide).The reaction of amine with the C=N of imine occurs without catalyst and is an easier process than its addition to C=O.This behaviour is also displayed by a number of aromatic heterocycles and homocyclic amines and may be explained by considering the activating effect of the electron-withdrawing group present in the imine moiety.