107986-49-2

Basic information

• Product Name: 2-Acetamido-4-bromophenol
• Synonyms: 2-Acetamido-4-bromophenol;N-(5-Bromo-2-hydroxyphenyl)acetamide;N-Acetyl 5-bromo-2-hydroxyaniline
• CAS NO: 107986-49-2
• Molecular Formula: C₈H₈BrNO₂
• Molecular Weight: 230.05862
• Mol File: 107986-49-2.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Acetamido-4-bromophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Acetamido-4-bromophenol(107986-49-2)
• EPA Substance Registry System: 2-Acetamido-4-bromophenol(107986-49-2)

Safety Data

• Hazardous Substances Data: 107986-49-2(Hazardous Substances Data)

Usage

General Description

2-Acetamido-4-bromophenol is a chemical compound with the molecular formula C8H8BrNO2. It is a pale yellow solid that is commonly used as an intermediate in the synthesis of pharmaceuticals and organic materials. 2-Acetamido-4-bromophenol contains both an acetamido group and a bromophenol group, making it useful in a variety of chemical reactions. It is known for its antimicrobial properties and is often used in the production of antifungal and antibacterial agents. Additionally, it is used in the synthesis of dyes and as a reagent in organic chemistry reactions. Overall, 2-Acetamido-4-bromophenol is a versatile chemical with various industrial applications.

Upstream product

• 2163-77-1 3-amino-4-hydroxyphenylarsonic acid 
• 97-44-9 acetarsone 
• 614-80-2 2-(acetylamino)phenol 
• 40925-68-6 2-amino-4-bromo-phenol 
• 123-54-6 acetylacetone 
• 95-55-6 2-amino-phenol 
• 65440-82-6 O-(4-bromophenyl)hydroxylamine 
• 328081-49-8 (p-bromo-N-phenoxy)phthalimide 
• 5467-74-3 4-Bromophenylboronic acid 
• 75-36-5 acetyl chloride 
• 7693-52-9 4-bromo-2-nitrophenol 
• 106-41-2 4-bromo-phenol 
• 36749-01-6 2-acetamido-4-bromophenyl acetate 
• 108-24-7 acetic anhydride 

Downstream Products

• 88301-40-0 N-(5-bromo-2-methoxyphenyl)acetamide 
• 1256360-26-5 N-[2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamide 
• 70977-85-4 1-(2-hydroxy-3-amino-5-bromophenyl)ethan-1-one 
• 40925-68-6 2-amino-4-bromo-phenol 
• 24036-48-4 2-chloro-N-(5-bromo-2-hydroxyphenyl)acetamide 
• 1053733-51-9 (3aS,4R,8R,8aS)-5,7-Bis-(3-acetyl-benzyl)-2,2-dimethyl-4,8-bis-(4-methyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethyl)-hexahydro-1,3-dioxa-5,7-diaza-azulen-6-one 
• 105655-01-4 6-bromo-3, 4-dihydro-2H-benzo[β][1, 4]oxazine 

Relevant articles and documents

A phenol compound high regioselective bromination method

The invention discloses a phenol compound high regioselective bromination of the method, the method to trimethyl silane as brominating agent, in order to aryl sulfoxide as activator, with the phenol compound in the 0 - 50 °C lower, in a solvent, the reaction is stirred under an atmosphere of nitrogen at 1 - 12 hours, to realize the phenol compound high regioselective bromination, filtered, extraction columns chromatography separation to obtain the bromo phenol compound. This invention adopts the aryl sulfoxide as activator, sulfoxide substituted Kiev, on the one hand so that the phenol compound bromo the higher selectivity of the reaction region, and when the phenol compound hydroxy alignment not substituted basetime, regional selective para - bromo product, when the phenol compound hydroxy position there is substituted basetime, selective ortho - bromo product obtained; on the other hand if it through the filter, the extraction can be realized at the same time the isolation and purification of the recycling of the by-product, compared with column chromatography, reduces the separation and purification cost.

INHIBITORS OF CBL-B AND METHODS OF USE THEREOF

Compounds, compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells in vivo, in vitro, or ex vivo.

Cp?Rh(III)/Bicyclic Olefin Cocatalyzed C-H Bond Amidation by Intramolecular Amide Transfer

A bicyclic olefin was discovered as a cocatalyst in a Cp?Rh(III)-catalyzed C-H bond amidation proceeding by an intramolecular amide transfer in N-phenoxyacetamide derivatives. Combining experimental and theoretical studies, we propose that the olefin promotes a Rh(III) intermediate to undergo oxidative addition into the O-N bond to form a Rh(V) nitrenoid species and subsequently direct the nitrenoid to add to the ortho position. The amide directing group plays a dual role as a cleavable coordinating moiety as well as an essential coupling partner for the C-H amidation. This methodology was successfully applied to the late-stage diversification of natural products and a marketed drug under mild conditions.