1080555-76-5Relevant articles and documents
PROCESS FOR THE PREPARATION OF VALSARTAN
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Page/Page column 11, (2009/01/20)
The present invention relates to a process for preparing valsartan from a compound of general formula (I), wherein R is cumyl, trityl or t-butyl. The process comprises a first step, wherein the protective group is eliminated and thereafter the oxazolidinone ring is opened by catalytic hydrogenationin the presence of an organic base. Finally, Valsartanor a pharmaceutically acceptable salt thereofis isolated.