1082077-26-6

Basic information

• Product Name: (S)-3-(isopropoxycarbonylamino-methyl)-5-methyl-hexanoic acid (S)-(-)-1-phenylethylamine salt
• Synonyms: (S)-3-(isopropoxycarbonylamino-methyl)-5-methyl-hexanoic acid (S)-(-)-1-phenylethylamine salt
• CAS NO: 1082077-26-6
• Molecular Weight: 366.501
• Mol File: 1082077-26-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (S)-3-(isopropoxycarbonylamino-methyl)-5-methyl-hexanoic acid (S)-(-)-1-phenylethylamine salt(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-(isopropoxycarbonylamino-methyl)-5-methyl-hexanoic acid (S)-(-)-1-phenylethylamine salt(1082077-26-6)
• EPA Substance Registry System: (S)-3-(isopropoxycarbonylamino-methyl)-5-methyl-hexanoic acid (S)-(-)-1-phenylethylamine salt(1082077-26-6)

Safety Data

• Hazardous Substances Data: 1082077-26-6(Hazardous Substances Data)

Upstream product

• 1082077-22-2 isopropyl {4-methyl-2-[(1-carboxy)-methyl]-pentyl}-carbamate 
• 2627-86-3 (S)-1-phenyl-ethylamine 

Downstream Products

• 148553-50-8 pregabilin 

Relevant articles and documents

PROCESS FOR THE SYNTHESIS OF PREGABALIN

A process for the preparation of a compound of formula (I) is disclosed, which comprises: a) the reaction of a compound of formula (II) with zinc azide of formula (III) [in-line-formulae]Zn(N3)2??(III)[/in-line-formulae]in the presence of a solvent of formula R1—OH, wherein R1 is herein defined, to obtain a compound of formula (IV), b) its conversion into a compound of formula (V); c) its enantiomeric enrichment to obtain the (S) enantiomer of formula (VI); and d) the hydrolysis thereof.

A process for the preparation of (S)(+)-3-(aminomethyl)-5-methylhexanoic acid

A process for the preparation of a compound of formula (I), comprising: a) the reaction of a compound of formula (II) with hydrazine to obtain a compound of formula (III), b) the conversion of a compound of formula (III) by rearrangement via formation of nitrene/isocyanate, in a solvent of formula R1-OH, wherein R1 is as herein defined, to obtain a compound of formula (IV); c) the enantiomeric enrichment of a compound of formula (IV) to obtain the enantiomer (S) of a compound of formula (V) d) the hydrolysis of a compound of formula (V).