1082204-05-4Relevant articles and documents
Discovery of a potent, selective and orally bioavailable 3,9-diazaspiro[5.5]undeca-2-one CCR5 antagonist
Yang, Hanbiao,Lin, Xiao-Fa,Padilla, Fernando,Gabriel, Stephen D.,Heilek, Gabrielle,Ji, Changhua,Sankuratri, Surya,deRosier, Andre,Berry, Pamela,Rotstein, David M.
scheme or table, p. 209 - 213 (2009/05/26)
Replacement of the cyclic carbamate in our previously disclosed 1-oxa-3,9-diazaspiro[5.5]undecan-2-one template led to the discovery of two novel series of 3,9-diazaspiro[5.5]undecane and undeca-2-one CCR5 antagonists. The synthesis, SAR, and antiviral ac
Heterocyclic antiviral compounds
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Page/Page column 14, (2009/12/04)
This invention relates to piperidine derivatives of formula I wherein R1, R2 and R3 are as defined herein useful in the treatment of a variety of disorders, including those in which the modulation of CCR5 receptors is impl