1085938-52-8Relevant articles and documents
Itk kinase inhibitors: Initial efforts to improve the metabolical stability and the cell activity of the benzimidazole lead
Moriarty, Kevin J.,Winters, Michael,Qiao, Lei,Ryan, Declan,DesJarlis, Renee,Robinson, Darius,Cook, Brian N.,Kashem, Mohammed A.,Kaplita, Paul V.,Liu, Lisa H.,Farrell, Thomas M.,Khine, Hnin Hnin,King, Josephine,Pullen, Steven S.,Roth, Gregory P.,Magolda, Ronald,Takahashi, Hidenori
scheme or table, p. 5537 - 5540 (2009/06/30)
Previously, we reported a series of novel benzimidazole based Itk inhibitors that exhibited excellent enzymatic potency and selectivity but low microsomal stability. Employing a structure based approach a new series of inhibitors with comparable potency a