108661-89-8

Basic information

• Product Name: (2-BROMO-1,1-DIFLUOROETHYL)BENZENE
• Synonyms: (2-BROMO-1,1-DIFLUOROETHYL)BENZENE;(2-Bromo-1,1-difluoroethyl)benzene 98%;(2-Bromo-1,1-difluoroethyl)benzene98%;REF DUPL: (2-Bromo-1,1-difluoroethyl)benzene;1-(2-broMo-1,1-difluoro-ethyl)benzene
• CAS NO: 108661-89-8
• Molecular Formula: C8H7BrF2
• Molecular Weight: 221.04
• Mol File: 108661-89-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: -26--24℃
• Boiling Point: 41°C
• Flash Point: 77.228 °C
• Appearance: cream
• Density: 1.502 g/cm³
• Vapor Pressure: 0.383mmHg at 25°C
• Refractive Index: 1.5131 (589.3 nm 20℃)
• CAS DataBase Reference: (2-BROMO-1,1-DIFLUOROETHYL)BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: (2-BROMO-1,1-DIFLUOROETHYL)BENZENE(108661-89-8)
• EPA Substance Registry System: (2-BROMO-1,1-DIFLUOROETHYL)BENZENE(108661-89-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 108661-89-8(Hazardous Substances Data)

Usage

General Description

(2-Bromo-1,1-difluoroethyl)benzene, also known as bromo-difluoroethylbenzene, is a chemical compound with the formula C8H6BrF2. It is a colorless to pale yellow liquid with a sweet, aromatic odor. (2-Bromo-1,1-difluoroethyl)benzene is primarily used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. Its unique structure and properties make it a valuable intermediate in organic and medicinal chemistry. However, it is important to handle this compound with caution, as it is toxic and may cause irritation to the skin, eyes, and respiratory system. Additionally, it may have harmful effects on the environment if not properly handled and disposed of.

InChI:InChI=1/C8H7BrF2/c9-6-8(10,11)7-4-2-1-3-5-7/h1-5H,6H2

Upstream product

• 100-42-5 styrene 
• 1786-36-3 (2-bromo-1-fluoroethyl)benzene 
• 70-11-1 α-bromoacetophenone 
• 696-31-1 α-fluorostyrene 

Downstream Products

• 233280-91-6 2-acetoxy-1,1-difluoro-1-phenylethane 
• 1227622-68-5 3-[5-chloro-2-(2,2-difluoro-2-phenyl-ethoxy)-phenoxy]-azetidine-1-carboxylic acid tert-butyl ester 
• 129973-45-1 2,2-Difluoro-2-phenyl-1-(phenylthio)ethyl acetate 
• 129973-42-8 2,2-Difluoro-2-phenylethyl phenyl sulfone 
• 129973-49-5 2,2-Difluoro-2-phenyl-1-(phenylthio)ethanol 
• 129973-41-7 2,2-Difluoro-2-phenylethyl phenyl sulfoxide 
• 261518-58-5 ethyl (E)-4,4-difluoro-4-phenylbut-2-enoate 
• 762292-95-5 3,3-difluoro-2-hydroxy-3-phenylpropionic acid 
• 762292-90-0 2-amino-3,3-difluoro-3-phenylpropionic acid 
• 144156-71-8 Ethyl 3,3-difluoro-2-hydroxy-3-phenylpropanoate 
• 144156-72-9 Ethyl 3,3-difluoro-2-oxo-3-phenylpropanoate 
• 144156-73-0 3,3-Difluoro-2-oxo-3-phenylpropanoic acid 
• 144156-69-4 3,3-Difluoro-2-hydroxy-3-phenylpropanenitrile 
• 129973-51-9 2,2-difluoro-2-phenylethan-1-ol 

Relevant articles and documents

Vicinal bromofluoroalkanes: Their regioselective formation and their conversion to fluoroolefins

The reaction of alkenes with N-bromosuccinimide and triethylamine tris(hydrofluoride) produces vic-bromofluoroalkanes (1) with high yields. As long as the addition to the double bond is sterically unhindered, bromine and fluorine get attached with very high regioselectivity, the latter halogen occupying the more substituted, carbocation stabilizing position. 2-Fluoro-1-alkenes give 1-bromo-2,2-di-fluoroalkanes (4). The heavier halogen may be removed by base promoted dehydro-fluorination, to afford fluoroolefins (2), or by reduction with tributyltin hydride, leading to mono- or difluoroalkanes (e.g., 5).

Synthesis of γ-Fluoro-α,β-unsaturated Carboxylic Esters from Saturated α-Fluoro Aldehydes

γ-Fluoro-α,β-unsaturated carboxylic esters 7a, 7b and 7d and 4-fluoro-4-phenylbut-3-enoic ester (8) are obtained by two alternative pathways from 2-fluoro aldehydes 5a-d, either by Horner-Wadsworth-Emmons reaction or by Wittig reaction. The aldehydes 5a-d are prepared by Swern oxidation of the corresponding fluorohydrins 4a-d. These are available from α-olefins by bromofluorination, bromine-by-acetate replacement and subsequent hydrolysis.