109113-98-6

Basic information

• Product Name: 6-(trifluoromethyl)imidazo[2,1-b]thiazole
• Synonyms: 6-(trifluoromethyl)imidazo[2,1-b]thiazole
• CAS NO: 109113-98-6
• Molecular Formula: C6H3F3N2S
• Molecular Weight: 192.1616296
• Mol File: 109113-98-6.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Density: 1.654g/cm³
• Refractive Index: 1.606
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.38±0.40(Predicted)
• CAS DataBase Reference: 6-(trifluoromethyl)imidazo[2,1-b]thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(trifluoromethyl)imidazo[2,1-b]thiazole(109113-98-6)
• EPA Substance Registry System: 6-(trifluoromethyl)imidazo[2,1-b]thiazole(109113-98-6)

Safety Data

• Hazardous Substances Data: 109113-98-6(Hazardous Substances Data)

Usage

General Description

6-(trifluoromethyl)imidazo[2,1-b]thiazole is a chemical compound with the molecular formula C6H3F3N2S. It is a heterocyclic compound containing both nitrogen and sulfur in its ring structure. This chemical is commonly used in the pharmaceutical and agrochemical industries as a building block in the synthesis of various biologically active compounds. It has been studied for its potential biological activities and has shown promise as an antifungal and antibacterial agent. Additionally, it has been investigated for its potential use in the development of new drugs for the treatment of various diseases. Its unique structure and properties make it a valuable chemical in the field of medicinal and agricultural chemistry.

InChI:InChI=1/C6H3F3N2S/c7-6(8,9)4-3-11-1-2-12-5(11)10-4/h1-3H

Upstream product

• 96-50-4 2-thiazolylamine 
• 169260-95-1 2-Trifluoromethyl-2-phenylsulfonyloxirane 
• 431-35-6 3-bromo-1,1,1-trifluoroacetone 

Downstream Products

• 1257653-74-9 (E)-3-(6-(trifluoromethyl)imidazo[2,1-b]thiazol-5-yl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one 
• 1257653-76-1 (E)-3-(6-(trifluoromethyl)imidazo[2,1-b]thiazol-5-yl)-1-(3,4-dimethoxyphenyl)prop-2-en-1-one 
• 1007874-87-4 6-trifluoromethyl-imidazo[2,1-b]thiazole-5-carboxylic acid 
• 564443-27-2 6-(trifluoromethyl)imidazo[2,1-b]thiazol-5-carbaldehyde 

Relevant articles and documents

Synthesis of imidazothiazole-chalcone derivatives as anticancer and apoptosis inducing agents

A new class of imidazo[2,1-b]thiazole chalcone derivatives were synthesized and evaluated for their anticancer activity. These chalcone derivatives show promising activity, with logGI50 values ranging from -7.51 to -4.00. The detailed biological aspects of these derivatives toward the MCF-7 cell line were studied. Interestingly, these chalcone derivatives induced G 0/G1-phase cell-cycle arrest, down-regulation of G 1-phase cell-cycle regulatory proteins such as cyclin D1 and cyclin E1, and up-regulation of CDK4. Moreover, these compounds elicit the characteristic features of apoptosis such as enhancement in the levels of p53, p21, and p27, suppression of NF-κB, and up-regulation of caspase-9. One of these chalcone derivatives, 3d, is potentially well suited for detailed biological studies, either alone or in combination with existing therapies. Breaking the cycle: We undertook an extensive examination of the ability of a series of new chalcone derivatives to regulate the cell cycle and to induce apoptosis in various cancer cell lines. Compound 3d is a particularly suitable candidate for further detailed biological investigations, especially in the treatment of breast cancer.

TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES

The invention relates to novel trans-3-aza-bicyclo[3.1.0]hexane derivatives of formula (I), wherein A, B, n and R1 are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists.

α- or β-Trifluoromethyl epoxysulfones: new C3 reagents for heterocyclisation

The syntheses of α- and β-trifluoromethyl epoxysulfones 1 and 2 are described.Compound 1 reacts with nucleophiles and bis-nucleophiles to furnish trifluoromethyl ketones and trifluoromethyl heterocycles in good yield, while its isomer 2 leads to the opposite thiazole regioisomers with thioamides. - Keywords: Trifluoromethyl epoxysulfones; Heterocyclisation; Regioisomers; NMR spectroscopy; IR spectroscopy