1092484-56-4 Usage
Description
Fenofibrate-d6 is a deuterated analog of fenofibrate, intended for use as an internal standard for the quantification of fenofibrate by gas chromatography-mass spectrometry (GC-MS) or liquid chromatography-mass spectrometry (LC-MS). It is a white solid and acts as an agonist of peroxisome proliferator-activated receptor α (PPARα), with selectivity over PPARγ and no activity at PPARδ. Fenofibrate-d6 has been shown to reduce plasma levels of triglycerides, C-reactive protein, and malondialdehyde (MDA) in mice with fructose-induced hypertriglyceridemia, as well as decrease glomerular and tubular atrophy and necrosis induced by cisplatin in rat kidneys and reduce the number of pulmonary lesions induced by 4-nitroquinoline 1-oxide (4-NQO) in lung of Tsumura Suzuki obese diabetic (TSOD) mice.
Uses
1. Used in Pharmaceutical Industry:
Fenofibrate-d6 is used as an internal standard for the quantification of fenofibrate in pharmaceutical research and development. It aids in the accurate measurement of fenofibrate levels in various applications, ensuring the efficacy and safety of the drug.
2. Used in Lipid Regulation:
Fenofibrate-d6 is used as an antilipemic agent, functioning as a lipid-regulating drug. It increases high-density lipoprotein (HDL) levels by reducing cholesteryl ester transfer protein expression, thus contributing to the management of dyslipidemia and associated health risks.
3. Used in Research and Development of PPARα Agonists:
Fenofibrate-d6 serves as a valuable tool in the research and development of PPARα agonists. Its selective activation of PPARα over PPARγ and lack of activity at PPARδ makes it an important compound for studying the effects and potential applications of PPARα agonists in various diseases and conditions.
4. Used in Toxicology and Drug Safety Studies:
Fenofibrate-d6 is utilized in toxicology and drug safety studies to evaluate the potential adverse effects of fenofibrate and other related compounds. Its use in these studies helps to determine the safety profile of these drugs and their potential for causing harm in various organ systems.
5. Used in Analytical Chemistry:
Fenofibrate-d6 is employed as a reference compound in analytical chemistry, particularly in the development and validation of GC-MS and LC-MS methods for the analysis of fenofibrate and its metabolites. Its stable isotopic composition ensures accurate and reliable quantification of the target analyte in complex biological samples.
Check Digit Verification of cas no
The CAS Registry Mumber 1092484-56-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,9,2,4,8 and 4 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1092484-56:
(9*1)+(8*0)+(7*9)+(6*2)+(5*4)+(4*8)+(3*4)+(2*5)+(1*6)=164
164 % 10 = 4
So 1092484-56-4 is a valid CAS Registry Number.
