1092536-44-1Relevant articles and documents
Synthesis and preferred all-syn conformation of C3-symmetrical N-(hetero)arylmethyl triindoles
Garcia-Frutos, Eva M.,Gomez-Lor, Berta,Monge, Angeles,Gutierrez-Puebla, Enrique,Alkorta, Ibon,Elguero, Jose
, p. 8555 - 8561 (2008)
A new series of C3-symmetrical N-(hetero)arylmethyl triindoles has been synthesized in a straightforward procedure. The structure and conformation in the solid state have been determined for three derivatives (3, 4, and 6) by X-ray crystallographic analysis. In all three cases, the molecules adopt a tripodal conformation with all of the flexible arms directed towards the same side, thereby delimiting an inner cavity. Compound 6 crystallizes and forms C3-symmetric dimeric cage-like complexes. Guest molecules of chloroform and water are confined within the resulting cavities with stabilization by different intermolecular interactions; this highlights the potential of these compounds in the construction of supramolecular systems. A computational analysis has been performed to predict the most stable conformers. As a general trend, a preference for a conformation with all branches directed to the same side has been predicted. Comparison between theoretical and experimental results indicates that the computational level selected for the present study, B3LYP/6-31G*, is able to reproduce both the minimum energy conformations and the rotation barriers about the N-CH2 bond.
N-Bromosuccinimide mediated synthesis of triazatruxenes from indoles
Toworakajohnkun, Natthawut,Sukwattanasinitt, Mongkol,Rashatasakhon, Paitoon
supporting information, p. 4149 - 4152 (2017/09/29)
A new synthetic method for triazatruxenes from indoles is developed using N-bromosuccinimide (NBS) as a user-friendly reagent. Major reaction parameters including the amount of NBS, substrate concentration, temperature, addition rate and addition method are investigated. Additional experiments are also conducted in order to gain access toward the reaction mechanism. Compared to the use of Br2 in the conventional method, this reaction requires less reaction time, provides better yields, and displays excellent reproducibility. The reaction can be conveniently performed at 10 g scale and it is also applicable to several substituted indoles, benzoindole, and N-alkyl indoles.