109430-87-7Relevant articles and documents
ASYMMETRIC SYNTHESIS VIII: ENANTIONSELECTIVE SYNTHESIS OF (R) OR (S)-α-SUBSTITUTED BENZYLAMINES VIA CHIRAL PINANONE KETIMINE TEMPLATE
Yuanwei, Chen,Aiqiao, Mi,Xun, Xiao,Yaozhong, Jiang
, p. 1423 - 1430 (2007/10/02)
An excellent asymmetric synthesis of both (R) and (S)-α-substituted benzylamines in optical purity 90.4 - 99.9percent has been achieved by alkylation of a chiral ketimine, prepared from pinanone and benzylamine.Diastereoselectivity in the alkylation is not dependent on the alkyl halides.
Synthesis and structure-activity relationships of 1-substituted 4-(1,2-diphenylethyl)piperazine derivatives having narcotic agonist and antagonist activity
Natsuka,Nakamura,Nishikawa,Negoro,Uno,Nishimura
, p. 1779 - 1787 (2007/10/02)
Racemates and enantiomers of 1-substituted 4-[2-(3-hydroxyphenyl)-1-phenylethyl]piperazine derivatives (3-18) were synthesized, and their analgesic and other pharmacological activities and structure-activity relationships were investigated. The S-(+) enan