109431-87-0Relevant articles and documents
Enantiospecific Synthesis of the (4R)-1-Azabicycloheptane Ring System
Houghton, Peter G.,Humphrey, Guy R.,Kennedy, Derek J.,Roberts, D. Craig,Wright, Stanley H. B.
, p. 1421 - 1424 (1993)
An enantioselective synthesis of (4R)-1-azabicycloheptane derivatives is described commencing from readily available trans-4-hydroxy-L-proline which is converted into the key intermediate (3R)-N-(tert-butoxycarbonyl)-3-methylsulfonyloxypyrrolidine 4.Reaction of the sulfonate ester 4 with an enolate anion yields a mixtute of (3R)-pyrrolidineacetic esters 8 and 9 which are reduced to the corresponding alcohols 10 and 11.Conversion of the alcohols into the sulfonate esters 12 and 13 followed by deprotection of the pyrrolidine nitrogen leads to cyclisation yielding the (4R)-1-azabicycloheptane derivatives 14 and 15.
NOVEL OXADIAZOLES
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Page/Page column 96-97, (2020/05/15)
The present invention relates to novel compound of Formula I, wherein, R1, A1, A2, A3, A4, A5, L1, A, L2 and R2 are as defined in the detailed description. The present invention also relates to a combination or a composition comprising the compound of Formula I.
A fang chanfu law compound and its preparation method, pharmaceutical composition and use thereof
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Paragraph 0022; 0023; 0024; 0027; 0028, (2018/03/02)
The invention relates to a new compound for conversion of auricular fibrillation, as shown in the general formula i in the specification (n in the formula is equal to 0 to 4), or pharmaceutically acceptable salt thereof. The invention also provides a novel compound used as a preventive medicine or therapeutic drug for atrial fibrillation, a preparation method and a pharmaceutical composition containing the compound.