109466-88-8

Basic information

• Product Name: 2-AMINO-4-(TRIFLUOROMETHYL)BENZALDEHYDE
• Synonyms: 2-AMINO-4-(TRIFLUOROMETHYL)BENZALDEHYDE
• CAS NO: 109466-88-8
• Molecular Formula: C₈H₆F₃NO
• Molecular Weight: 189.13
• Mol File: 109466-88-8.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-AMINO-4-(TRIFLUOROMETHYL)BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-4-(TRIFLUOROMETHYL)BENZALDEHYDE(109466-88-8)
• EPA Substance Registry System: 2-AMINO-4-(TRIFLUOROMETHYL)BENZALDEHYDE(109466-88-8)

Safety Data

• Hazardous Substances Data: 109466-88-8(Hazardous Substances Data)

Usage

Structure

Trifluoromethyl derivative of benzaldehyde with an amino group and a trifluoromethyl group attached to the benzene ring.

Common Uses

Building block in organic synthesis
Reagent in the synthesis of various heterocyclic compounds
Flavoring agent in the food industry

Applications

Pharmaceutical industry
Agrochemical industry
Materials science
Precursor to various fine chemicals

Upstream product

• 109134-07-8 t-butyl<3-(trifluoromethyl)phenyl>-carbamate 
• 68-12-2 N,N-dimethyl-formamide 
• 402-13-1 2-amino-4-trifluoromethylbenzoic acid 
• 186602-93-7 [2-amino-4-(trifluoromethyl)phenyl]methan-1-ol 
• 400-98-6 4-trifluoromethyl-2-nitroaniline 
• 109466-86-6 4-(trifluoromethyl)-2-nitrobenzaldehyde oxime 
• 98-16-8 3-trifluoromethylaniline 
• 109466-87-7 4-(trifluoromethyl)-2-nitrobenzaldehyde 

Downstream Products

• 355399-89-2 [(5-Trifluoromethyl-2-formyl-phenylcarbamoyl)-methyl]-phosphonic Acid Diethyl Ester 
• 355399-88-1 [2-Oxo-6-phenyl-7-(trifluoromethyl)-1,2-dihydro-3-quinolyl]phosphonic acid diethyl ester 
• 324-32-3 2-methyl-7-trifluoromethylquinoline 
• 1395473-92-3 (S)-2-(4-methoxyphenyl)-7-(trifluoromethyl)-1,2,3,4-tetrahydroquinoline 
• 1254343-12-8 (S)-2-phenyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroacridine 
• 849543-30-2 ethyl 7-(trifluoromethyl)-2-oxo-1,2-dihydroquinoline-3-carboxylate 

Relevant articles and documents

Synthesis of quinolines and naphthyridines: Via catalytic retro-aldol reaction of β-hydroxyketones with ortho -aminobenzaldehydes or nicotinaldehydes

A Cu(i)-catalyzed retro-aldol reaction of β-hydroxyketones with ortho-aminobenzaldehydes and nicotinaldehydes is reported that produces a range of quinolines and naphthyridines with high efficiency and selectivity. This reaction uses β-hydroxyketones as a regiospecific ketone-protected enolate source via copper-catalyzed retro-aldol Cα-Cβ bond cleavage. The in situ generated copper enolate undergoes kinetically favorable cyclization with ortho-amino aryl aldehydes to produce quinolines and naphthyridines in a chemo- and regioselective manner. The mild and weakly basic reaction conditions also suppress possible side reactions of benzaldehydes under strongly basic conditions, resulting in improved reaction yields.

Cationic Iridium-Catalyzed Asymmetric Decarbonylative Aryl Addition of Aromatic Aldehydes to Bicyclic Alkenes

We report an unprecedented catalytic protocol for the enantioselective decarbonylative transformation of aryl aldehydes. In this process, the decarbonylation of aldehydes catalyzed by chiral iridium complexes enabled the formation of asymmetric C?C bonds

QUINOLIN-2-ONE DERIVATIVES

Compounds of the formula (I) in which X1, X2, X3, X4, R1, R2, R3, Q and Y have the meanings indicated in Claim 1, are inhibitors of c-Kit kinase, and can be employed for the treatment of cancer.