1096-84-0Relevant articles and documents
Reactions of naphthols with halogenmethanes under alkaline conditions
Brieskorn,Kallmayer
, p. 141 - 148 (1972)
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Dibromomethane as one-carbon source in organic synthesis: The Mannich base formation from the reaction of phenolic compounds with a preheated mixture of dibromomethane and diethylamine
Hon, Yung-Son,Chou, Yu-Yu,Wu, I-Che
, p. 2253 - 2267 (2004)
The salt formed from the reaction of dihalomomethane and diethylamine reacted with phenolic compounds to give the corresponding Mannich bases in modest to good yields. As for the relative rates and yields are in the following order: CH2Br2 > CH2Cl2. The CD2Cl2 is also applicable to prepare the deuterated analogues. At higher temperature, the elimination of diethylamine from Mannich base occurred to give the corresponding o-quinone methide intermediate, which was then trapped by another phenolic compound to give bis(2-hydroxy-1-aryl) methanes.
Naphthalene Tetrachlorides and Related Compounds. Part 12. Influence of Some 1-Substituents on the Course of Chlorination of Derivatives of 2-Naphthol
Calvert, David J.,Mare, Peter B. D. de la,Suzuki, Hitomi
, p. 255 - 260 (1983)
The chlorinations of 1-methyl-2-naphthol, 1-bromo-2-naphthol, 2,2'-dihydroxy-1,1'-dinaphthylmethane, and 6-t-butyl-2-naphthol with excess of chlorine in acetic acid give tetralin-2-ones analogous to that formed from 1-chloro-2-naphthol. 1,6-Di-t-butyl-2-naphthol, however, gives only 1,6-di-t-butyl-1,3-dichloro-1,2-dihydronaphthalene; 1-iodo-2-naphthol gives some 1,1,3,4-tetrachlorotetralin-2-one in acetic acid, whereas in chloroform it gives a mixture from which r-1,c-2,t-3,t-4,5,7-hexachlorotetralin-6-ol was isolated.The structures of these products and the pathways leading to them are discussed.
Guest-Reaction Driven Cage to Conjoined Twin-Cage Mitosis-Like Host Transformation
Cai, Li-Xuan,Cheng, Pei-Ming,Hu, Shao-Jun,Li, Shao-Chuan,Sun, Qing-Fu,Yan, Dan-Ni,Zhou, Li-Peng
, p. 23569 - 23573 (2020)
We report here a guest-reaction-induced mitosis-like host transformation from a known Pd4L2 cage 1 to a conjoined Pd6L3 twin-cage 2 featuring two separate cavities. The encapsulation of 1-hydroxymethyl-2-naphthol (G1), a known ortho-quinone methide (o-QMs) precursor, within the hydrophobic cavity of cage 1 is found crucial to realize the cage to twin-cage conversion. Confined G1 molecules within the nanocavity undergo self-coupling dimerization reaction to form 2,2′-dihydroxy-1,1′-dinaphthylmethane (G2) which then triggers the cage to twin-cage mitosis. The same conversion also proceeds, in a much faster rate, via the direct templation of G2, confirming the induced-fit transformation mechanism. The structure of the (G2)2?2 host–guest complex has been established by X-ray crystallographic study, where cis- to trans- conformational switch on one bridging ligand is revealed.
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de Diesbach,Wanger,v. Stockalper
, p. 355,357 (1931)
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Anticancer Activity and Catalytic Potential of Ruthenium(II)-Arene Complexes with N,O-Donor Ligands
Haghdoost, Mohammad Mehdi,Guard, Juliette,Golbaghi, Golara,Castonguay, Annie
, p. 7558 - 7567 (2018)
The special ability of organometallic complexes to catalyze various transformations might offer new effective mechanisms for the treatment of cancer. Studies that report both the biological properties and the ability of metallic complexes to promote therapeutically relevant catalytic reactions are limited. Herein, we report the anticancer activity and catalytic potential of some ruthenium(II)-arene complexes bearing bidentate Schiff base ligands (2a and 2b) and their reduced analogues (5a and 5b, respectively). In comparison to their Schiff base counterparts 2a and 2b, we demonstrate that amine complexes 5a and 5b display (i) a higher in vitro antiproliferative activity on different human cancer cell lines, (ii) a lower rate of hydrolysis, and (iii) an improved initial catalytic rate for the reduction of NAD+ to NADH. In contrast to their imine analogues 2a and 2b, we also show that amine complexes 5a and 5b induce the generation of intracellular reactive oxygen species (ROS) in MCF-7 breast cancer cells. Our results highlight the impact that a simple ligand modification such as the reduction of an imine moiety can have on both the catalytic and biological activities of metal complexes. Moreover, the ruthenium complexes reported here display some antiproliferative activity against T47D breast cancer cells, known for their cis-platin resistance.
Buu-Hoi,N.P. et al.
, p. 467 - 469 (1969)
ION CHANNEL ANTAGONISTS/BLOCKERS AND USES THEREOF
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Page/Page column 22; 24; 25; 63; 64; 74-76; 78; 79, (2021/06/22)
Provided are ion channel antagonists/blockers and uses thereof. Specifically, it provides the compounds of formula (I) or pharmaceutically acceptable salts, stereoisomers, solvates or prodrugs, preparation method therefor and application thereof. Definition of each group in the formula can be found in the specification for details. Provided is also pharmaceutical composition useful for treatment of heart disease and other ion channel related diseases.
NAPHTHALENE-CONTAINING POLYMERS AND METHODS OF MAKING THE SAME
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Paragraph 0083-0084, (2018/08/09)
The present disclosure relates to a dimer that includes a first hydroxyl-functionalized naphthalene group and a second hydroxyl-functionalized naphthalene group, where the first hydroxyl-functionalized naphthalene group and the second hydroxyl-functionalized naphthalene group are connected by a bridging group. The present disclosure also relates to a polymer synthesized using the dimer, as well as methods for synthesizing both the dimer and the polymer.
