110008-25-8Relevant articles and documents
Daunorubicin derivative and preparation method thereof and daunorubicin detection reagent
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Paragraph 0028; 0032, (2020/05/01)
The invention discloses a daunorubicin derivative for detecting the content of daunorubicin in a human body biological sample and a preparation method of the daunorubicin derivative. Three high-immunogenicity daunorubicin immunogens, three corresponding anti-daunorubicin specific antibodies and three daunorubicin enzyme-labeled conjugates are obtained by using the daunorubicin derivative, and three daunorubicin immunological detection reagents with high sensitivity, strong specificity and good detection effect are prepared. The invention also provides a preparation method and a corresponding use method of the three daunorubicin immunoassay reagents. The three daunorubicin immunodetection methods provided by the invention are convenient to operate, rapid in detection, accurate in result, high in sensitivity and strong in specificity, and can be used for quantitatively detecting the daunorubicin content in a human blood sample. The defects of complex operation, low automation degree andthe like of a daunorubicin detection method in the prior art are overcome, and clinical individualized reasonable medication can be effectively guided.
Novel compositions magnetic particles covered with gem-bisphosphonate derivatives
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, (2010/12/29)
The invention relates to a composition comprising acid magnetic particles (p) based on an iron compound, the acid magnetic particles (p) being complexed by one or more gem-bisphosphonate compounds, of formula I: [in-line-formulae]X-L-CH(PO3H2)2 ??(I)[/in-line-formulae]in which: L represents an organic group connecting the X group to the gem-bisphosphonate group —CH(PO3H2)2;X represents a chemical group capable of reacting with a biovector; all or some of the X groups of the particles optionally being coupled to a biovector. The invention relates also to a process for the preparation of the compositions and their use, in particular as contrast products for Magnetic Resonance Imaging (MRI).