110100-00-0

Basic information

• Product Name: Ethanone, 1-(2-chloro-5-pyrimidinyl)- (9CI)
• Synonyms: Ethanone, 1-(2-chloro-5-pyrimidinyl)- (9CI);1-(2-Chloro-pyriMidin-5-yl)-ethanone;[1-(2-ChloropyriMidin-5-yl)etanone;1-(2-Chloropyrimidin-5-yl)
• CAS NO: 110100-00-0
• Molecular Formula: C₆H₅ClN₂O
• Molecular Weight: 156.5697
• Product Categories: PYRIMIDINE
• Mol File: 110100-00-0.mol
• Article Data: 9

Chemical Properties

• Melting Point: 92 °C
• Boiling Point: 307.9±15.0 °C(Predicted)
• Appearance: /
• Density: 1.311±0.06 g/cm3(Predicted)
• Refractive Index: 1.538
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -3.29±0.22(Predicted)
• CAS DataBase Reference: Ethanone, 1-(2-chloro-5-pyrimidinyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(2-chloro-5-pyrimidinyl)- (9CI)(110100-00-0)
• EPA Substance Registry System: Ethanone, 1-(2-chloro-5-pyrimidinyl)- (9CI)(110100-00-0)

Safety Data

• Hazardous Substances Data: 110100-00-0(Hazardous Substances Data)

Usage

Description

Ethanone, 1-(2-chloro-5-pyrimidinyl)(9CI) is an organic compound that features a chlorinated pyrimidinyl group attached to an ethanone molecule. Ethanone, 1-(2-chloro-5-pyrimidinyl)(9CI) is known for its potential applications in various chemical and pharmaceutical processes due to its unique structural properties.

Uses

Used in Chemical Synthesis:
Ethanone, 1-(2-chloro-5-pyrimidinyl)(9CI) is used as a building block for the synthesis of 5-pyrimidinyl ketones with Mn(II) reagents. Its unique structure allows for the creation of a variety of complex molecules that can be utilized in different industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Ethanone, 1-(2-chloro-5-pyrimidinyl)(9CI) may be used as a key intermediate in the development of new drugs targeting various diseases. Its ability to form 5-pyrimidinyl ketones with Mn(II) reagents can lead to the creation of novel therapeutic agents with potential applications in treating a range of medical conditions.
Used in Research and Development:
Ethanone, 1-(2-chloro-5-pyrimidinyl)(9CI) can also be employed in research and development settings, where it can be used to study the properties and reactivity of chlorinated pyrimidinyl compounds. This knowledge can be applied to the design and synthesis of new molecules with specific biological activities or improved pharmaceutical properties.

InChI:InChI=1/C6H5ClN2O/c1-4(10)5-2-8-6(7)9-3-5/h2-3H,1H3

Upstream product

• 97674-02-7 tributyl(1-ethoxyvinyl)stannane 
• 32779-36-5 5-Bromo-2-chloropyrimidine 
• 917-54-4 methyllithium 
• 110099-99-5 2-CHLOROPYRIMIDINE-5-CARBONYLCHLORIDE 
• 122372-20-7 2-chloro-5-(α-ethoxyvinyl)pyrimidine 

Downstream Products

• 13426-94-3 N-methylbenzylamine hydrochloride 
• 1279822-48-8 1-(2-chloropyrimidin-5-yl) ethan-1-ol 
• 1279822-48-8 (S)-1-(2-chloropyrimidin-5-yl)ethanol 
• 265107-49-1 1-[2-(methylamino)pyrimidin-5-yl]ethanone 
• 1071323-12-0 1-(2-phenyl-pyrimidin-5-yl)-ethanone 
• 1569902-03-9 5-(1-methyl-prop-2-ynyl)-2-phenyl-pyrimidine 
• 1429200-46-3 1-(2-(((6-(bis(cyclopropylmethyl)amino)-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methyl)(3,5-bis(trifluoromethyl)benzyl)amino)pyrimidin-5-yl)ethanone 
• 1007883-29-5 2-bromo-1-(2-chloropyrimidin-5-yl)ethanone 
• 1254170-90-5 2-bromo-1-(2-bromopyrimidin-5-yl)ethanone 
• 1254171-25-9 5-(2-(2-chloro-6-fluorophenyl)-1H-imidazol-4-yl)-2-phenylpyrimidine 
• 110100-06-6 5-acetyl-1-benzyl-2(1H)-pyrimidinone 
• 87573-88-4 5-acetyl-2(1H)-pyrimidinone 

Relevant articles and documents

UNSATURATED HETEROCYCLOALKYL AND HETEROAROMATIC ACYL HYDRAZONE LINKERS, METHODS AND USES THEREOF

The present application is directed to compounds of Formula (I), (II), (III) or (IV) compositions comprising these compounds, methods for their preparation and their uses, for example, as acyl hydrazone linkers, which can link two chemical entities together for further use as medicaments and/or diagnostics.

cGAS ANTAGONIST COMPOUNDS

Disclosed are novel compounds of Formula (I) that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

GLYCOSIDASE INHIBITORS

Compounds of formula (I) wherein A, R, W, Q, n and m have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.