1101120-47-1

Basic information

• Product Name: 5-chloropyrazolo[1,5-a]pyridine
• Synonyms: 5-chloropyrazolo[1,5-a]pyridine
• CAS NO: 1101120-47-1
• Molecular Formula: C7H5ClN2
• Molecular Weight: 152.581
• Mol File: 1101120-47-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.35±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.01±0.30(Predicted)
• CAS DataBase Reference: 5-chloropyrazolo[1,5-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloropyrazolo[1,5-a]pyridine(1101120-47-1)
• EPA Substance Registry System: 5-chloropyrazolo[1,5-a]pyridine(1101120-47-1)

Safety Data

• Hazardous Substances Data: 1101120-47-1(Hazardous Substances Data)

Usage

General Description

5-chloropyrazolo[1,5-a]pyridine is a chemical compound with the molecular formula C6H4ClN3. It is a heterocyclic organic compound that contains a pyrazolo[1,5-a]pyridine ring with a chlorine substituent at the 5-position. 5-chloropyrazolo[1,5-a]pyridine has been studied for its potential pharmaceutical applications, particularly in the development of new drugs. It has been investigated as a potential building block for the synthesis of bioactive molecules and as a potential ligand for the development of new metal-based catalysts. Additionally, 5-chloropyrazolo[1,5-a]pyridine has been studied for its potential biological activities, including its interactions with various biological targets and its potential as a therapeutic agent in the treatment of different diseases.

Upstream product

• 1101120-37-9 pyrazolo[1,5-a]pyridin-5-amine 
• 1101120-33-5 5-[(tert-butoxycarbonyl)amino]pyrazolo[1,5-a]pyridine-3-carboxylic acid ethyl ester 
• 98400-69-2 N-(4-pyridyl) t-butyl carbamate 

Downstream Products

• 1101118-17-5 N'-((5-chloropyrazolo[1,5-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide 
• 1101120-49-3 5-chloropyrazolo[1,5-a]pyridine-3-carbaldehyde 

Relevant articles and documents

Discovery of pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors

We have made a novel series of pyrazolo[1,5-a]pyridines as PI3 kinase inhibitors, and demonstrated their selectivity for the p110α isoform over the other Class Ia PI3 kinases. We investigated the SAR around the pyrazolo[1,5-a]pyridine ring system, and found compound 5x to be a particularly potent example (p110α IC50 0.9 nM). This compound inhibits cell proliferation and phosphorylation of Akt/PKB, a downstream marker of PI3 kinase activity, and showed in vivo activity in an HCT-116 human xenograft model.

PYRAZOLOPYRIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS

In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyridine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, m