1105662-87-0

Basic information

• Product Name: 1-Boc-3-methoxycarbonylme...
• Synonyms: 1-Boc-3-methoxycarbonylme...;1-Boc-3-MethoxycarbonylMethylene-azetidine;tert-butyl 3-(2-Methoxy-2-oxoethylidene)azetidine-1-carboxylate;1-Azetidinecarboxylic acid, 3-(2-Methoxy-2-oxoethylidene)-, 1,1-diMethylethyl ester;1,3-Azetidinedicarboxylic acid, 1-(1,1-diMethylethyl) 3-Methyl ester
• CAS NO: 1105662-87-0
• Molecular Formula: C₁₁H₁₇NO₄
• Molecular Weight: 227.25698
• Mol File: 1105662-87-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 303.271 °C at 760 mmHg
• Flash Point: 137.214 °C
• Appearance: /
• Density: 1.219 g/cm³
• Storage Temp.: 2-8°C
• PKA: -1.69±0.20(Predicted)
• CAS DataBase Reference: 1-Boc-3-methoxycarbonylme...(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Boc-3-methoxycarbonylme...(1105662-87-0)
• EPA Substance Registry System: 1-Boc-3-methoxycarbonylme...(1105662-87-0)

Safety Data

• Hazardous Substances Data: 1105662-87-0(Hazardous Substances Data)

Usage

Uses

tert-Butyl 3-(2-methoxy-2-oxoethylidene)azetidine-1-carboxylate is a useful intermediate used in the preparation of spirocyclic β-proline esters that functions as building blocks for medicinal chemistry.

Upstream product

• 398489-26-4 tert-butyl 3-oxoazetidine-1-carboxylate 
• 1067-74-9 Methyl diethylphosphonoacetate 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 

Downstream Products

• 1105662-89-2 tert-butyl 3-amino-3-(2-methoxy-2-oxo-ethyl)azetidine-1-carboxylate 
• 402938-21-0 (Z)-methyl 3-[[(1,1-dimethylethoxycarbonyl)methylamino]methyl]-3-phenyl-2-propenoate 
• 55164-54-0 1,5-dihydro-1-methyl-4-phenyl-2H-pyrrol-2-one 

Relevant articles and documents

Synthesis of oxetane/azetidine containing spirocycles

Oxetane-benzopyran spirocycles were synthesised via a palladium catalysed cyclisation-cross coupling cascade reaction whilst oxetane/azetidine-pyrrolidino isoindolone spirocycles were synthesised via a silver catalysed 1,3-dipolar cycloaddition reaction f

Rhodium catalyzed C-C bond cleavage/coupling of 2-(azetidin-3-ylidene)acetates and analogs

The C-C bond cleavage/coupling of 2-(azetidin-3-ylidene)acetates with aryl boronic acids catalyzed by a rhodium complex was studied with a "conjugate addition/β-C cleavage/protonation" strategy.

Synthesis of 6-Azaspiro[4.3]alkanes: Innovative Scaffolds for Drug Discovery

New scaffolds for drug discovery, 6-azaspiro[4.3]alkanes, have been synthesized in two steps from four-membered-ring ketones: cyclobutanone, thienone, N-Boc-azetidinone (Boc = tert-butoxycarbonyl), etc. The key transformation was the reaction between electron-deficient exocyclic alkenes and an in-situ generated N-benzylazomethine ylide.