1108-68-5 Usage
General Description
Cinobufotalin is a chemical compound found in the venom of the Chinese toad, Bufo gargarizans and Bufo bufo. It is a type of bufadienolide, which is a class of organic compounds that belong to the steroid family. Cinobufotalin has been traditionally used in Chinese medicine for its cardiotonic, anti-inflammatory, and anti-tumor properties. It has been studied for its potential anticancer activities, particularly in liver, lung, and colon cancer cells. Additionally, it has been investigated for its potential in treating cardiac conditions, such as heart failure and arrhythmias. However, it is important to note that cinobufotalin can be toxic and should only be used under the guidance of a qualified healthcare professional.
Check Digit Verification of cas no
The CAS Registry Mumber 1108-68-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,0 and 8 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1108-68:
(6*1)+(5*1)+(4*0)+(3*8)+(2*6)+(1*8)=55
55 % 10 = 5
So 1108-68-5 is a valid CAS Registry Number.
InChI:InChI=1/C26H34O7/c1-14(27)32-21-20(15-4-5-19(29)31-13-15)24(3)10-7-17-18(26(24)22(21)33-26)8-11-25(30)12-16(28)6-9-23(17,25)2/h4-5,13,16-18,20-22,28,30H,6-12H2,1-3H3/t16-,17-,18+,20-,21+,22+,23+,24+,25-,26+/m0/s1
1108-68-5Relevant articles and documents
Studies on cytotoxic constituents from the skin of the toad Bufo bufo gargarizans
Zhao, Hu-Yi,Wu, Fu-Kai,Qiu, Ying-Kun,Wu, Zhen,Jiang, Yong-Tao,Chen, Ji-Yong
, p. 793 - 800 (2010)
To study the chemical composition of the skin of Bufo bufo gargarizans, many kinds of chromatography methods were used in the isolation procedures, while the structures of isolated compounds were determined on the basis of their NMR and MS spectral analysis. As a result, two new compounds were isolated from its ethanolic extract and characterized as cinobufotalin 3-nonanedioylarginine ester (8) and bufotalin 3-pimeloylarginine ester (14). Furthermore, 13 known compounds were obtained. Isolated bufadienolides showed significant inhibition effect against SMMC-7721 cell lines in vitro.