1108730-76-2Relevant articles and documents
Evaluation of the heterogeneously catalyzed strecker reaction conducted under continuous flow
Wiles, Charlotte,Watts, Paul
experimental part, p. 5597 - 5613 (2009/05/11)
Building on our experience of micro-reaction technology, we present herein the evaluation of an integrated borosilicate glass micro reactor in which 51 α-aminonitriles were synthesized via a series of continuous solution-phase and heterogeneously catalyzed reaction steps, affording analytically pure products in yields > 99.6%. As an extension to this, the ability to selectivity synthesize aldehydic Strecker products in the presence of ketonic functionalities was also investigated, concluding with the chemoselective synthesis of 2-(4-acetylphenyl)-2-(phenethylamino)acetonitrile whereby the desired product was obtained in 99.8% yield and quantitative purity. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
