111086-51-2

Basic information

• Product Name: (1S,2R)-1,2-Bis-(4-methoxy-2,6-dimethyl-phenyl)-ethane-1,2-diamine
• Synonyms: (1S,2R)-1,2-Bis-(4-methoxy-2,6-dimethyl-phenyl)-ethane-1,2-diamine
• CAS NO: 111086-51-2
• Molecular Weight: 328.455
• Mol File: 111086-51-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1S,2R)-1,2-Bis-(4-methoxy-2,6-dimethyl-phenyl)-ethane-1,2-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2R)-1,2-Bis-(4-methoxy-2,6-dimethyl-phenyl)-ethane-1,2-diamine(111086-51-2)
• EPA Substance Registry System: (1S,2R)-1,2-Bis-(4-methoxy-2,6-dimethyl-phenyl)-ethane-1,2-diamine(111086-51-2)

Safety Data

• Hazardous Substances Data: 111086-51-2(Hazardous Substances Data)

Upstream product

• 6267-34-1 2-bromo-5-methoxy-1,3-dimethyl-benzene 
• 874-63-5 3,5-dimethylmethoxybenzene 
• 19447-00-8 4-methoxy-2,6-dimethylbenzylaldehyde 
• 58519-80-5 meso-1,2-bis(2-hydroxyphenyl)-1,2-ethylenediamine 

Downstream Products

• 111086-52-3 C₁₈H₂₄N₂O₂ 

Relevant articles and documents

Ring-Substituted y1,2-Bis(4-hydroxyphenyl)ethylenediamine>dichloroplatinum(II) Complexes: Compounds with a Selective Effect on the Hormone-Dependent Mammary Carcinoma

dichloroplatinum(II) complexes with one substituent in the 2-position (CH3, CF3, F, Br, I: meso- and dl-1-PtCl2, meso-(3-5)-PtCl2, meso-(7 and 8)-PtCl2) or two substituents in the 2,6-position (CH3, Cl: meso-2-PtCl2, meso- and dl-6-PtCl2) in both benzene rings were synthesized and tested for estrogenic and toxic activities.Two complexes (meso-6-PtCl2 and meso-7-PtCl2) possess both effects.In comparative tests on estrogen receptor positive and negative mammary tumors in cell culture (MCF 7, ER+ and MDA-MB 231, ER-) and in animals (MXT, ER+ and MXT, ER-, mouse), meso-6-PtCl2 shows a selective effect on the estrogen receptor positive mammary carcinoma.A further increase of efficacy was achieved with the water-soluble (sulfato)platinum(II) derivative (meso-6-PtSO4).On the DMBA-induced hormone dependent mammary carcinoma of the SD rat, meso-6-PtSO4 is significantly more active than its ligand (meso-6) and cisplatin.