1112-29-4Relevant articles and documents
Role of base catalysts upon the Pudovik reaction: Unexpected synthesis of 1,2-dihydropyridine phosphonate derivatives
Albouy, Dominique,Lasperas, Monique,Etemad-Moghadam, Guita,Koenig, Max
, p. 2311 - 2314 (1999)
The role of base catalysts (CsNaX zeolite, hydrotalcite, triethylamine and pyridine derivatives) upon the regioselectivity of the Pudovik reaction is studied. The unexpected synthesis of stable 1,2-dihydropyridine phosphonate derivatives via a one-pot addition reaction under mild conditions is described.
Dual Radical/Polar Pudovik Reaction: Application Field of New Activation Methods
Semenzin, Delphine,Etemad-Moghadam, Guita,Albouy, Dominique,Diallo, Ousmane,Koenig, Max
, p. 2414 - 2422 (2007/10/03)
The Pudovik reaction (addition of organophosphorus compounds containing a labile P-H bond with alkenes and alkynes) can progess via a radical or (and) ionic mechanism. A comparative and systematic study including various reagents and different activation methods (heating, photochemical or ultrasonic irradiation, and dry medium supported reactions) is presented. Photolysis is the most efficient method for the radical processes, but in a few examples, ultrasonic irradiation can be more appropriate since the reaction time is shorter and ultrasound did not induce side-reactions (in particular Z/E isomerization). Dry medium process on basic solid support is the best anionic activation (yield, time, selectivity, purification facilities). Ultrasound, by its mechanical effects, can contribute to increase yield compared to the classical thermal method under these basic conditions. All the activation methods are efficient whatever the unsaturated substrates for the phosphine reactivity, whereas the appropriate activation method is exclusively determined by the nature of the unsaturated system for the thiophosphine (or phosphine oxide) reactivity.
SYNTHESE DE CONJUGUES GEM-BISPHOSPHONIQUES DE DERIVES DE LA CORTISONE
Guervenou, J.,Sturtz, G.
, p. 1 - 14 (2007/10/02)
Some gem-bisphosphonic cortico-steroid conjugates are prepared by esterification between gem-bisphosphonate carboxylic acids and steroid primary alcohols.These original products take place in a biological study about a delivery-targeting concept of active constituents in bone therapy, with the assistance of gem-bisphosphonic building-blocks. Key words: gem-bisphosphonate; gem-bisphosphonic; tetraethyl ethylidene gem-bisphosphonate; corticosteroids; esterification; anti-inflammatory; delivery-targeting concept.
