1114-76-7

Basic information

• Product Name: N,N-DIETHYLBUTYRAMIDE
• Synonyms: Butanamide, N,N-diethyl-;Butyramide, N,N-diethyl-;n,n-diethyl-butanamid;N,N-Diethylbutanamide;N,N-Diethyl-n-butyramide;N,N-DIETHYLBUTYRAMIDE;TIMTEC-BB SBB008344
• CAS NO: 1114-76-7
• Molecular Formula: C₈H₁₇NO
• Molecular Weight: 143.23
• Mol File: 1114-76-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 261.35°C (rough estimate)
• Flash Point: 78.2 °C
• Appearance: /
• Density: 0.8884
• Vapor Pressure: 0.227mmHg at 25°C
• Refractive Index: 1.4403
• PKA: -0.41±0.70(Predicted)
• CAS DataBase Reference: N,N-DIETHYLBUTYRAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-DIETHYLBUTYRAMIDE(1114-76-7)
• EPA Substance Registry System: N,N-DIETHYLBUTYRAMIDE(1114-76-7)

Safety Data

• Hazardous Substances Data: 1114-76-7(Hazardous Substances Data)

Usage

Uses

N,N-Diethylbutyramide is a compound that has been used as a pretreatment before N,N-Dimethyltryptamine (D469620) to decrease its hallucinogenic activity.

InChI:InChI=1/C8H17NO/c1-4-7-8(10)9(5-2)6-3/h4-7H2,1-3H3

Upstream product

• 109-89-7 diethylamine 
• 141-75-3 butyryl chloride 
• 4098-96-8 Phosphorigsaeure-butyrylester-butylester-diethylamid 
• 81054-12-8 dibromo-acetic acid diethylamide 
• 925-90-6 ethylmagnesium bromide 
• 123-72-8 butyraldehyde 
• 121-44-8 triethylamine 
• 1481-55-6 N-ethyl-N-(trifluoromethyl)ethanamine 
• 107-92-6 butyric acid 

Downstream Products

• 589-38-8 n-hexan-3-one 
• 24964-76-9 triethyl orthobutyrate 
• 14869-36-4 1-ethoxy-2-pentanone 
• 19420-07-6 N.N-Diethyl-thiobuttersaeureamid 
• 1129-50-6 N-phenylbutyramide 
• 74-84-0 ethane 
• 34557-54-5 methane 
• 107-87-9 2-Pentanone 
• 1616976-58-9 N,N-diethyl-2-[(2-phenylquinolin-4-yl)methyl]butanamide 

Relevant articles and documents

Chemo- and Stereoselective Transition-Metal-Free Amination of Amides with Azides

The synthesis of α-amino carbonyl/carboxyl compounds is a contemporary challenge in organic synthesis. Herein, we present a stereoselective α-amination of amides employing simple azides that proceeds under mild conditions with release of nitrogen gas. The

Niobium pentachloride promoted conversion of carboxylic acids to carboxamides: Synthesis of the 4-aryl-1,2,3,4-tetrahydroisoquinoline alkaloid structures

A practical method for the conversion of carboxylic acids to the corresponding carboxamides mediated by niobium pentachloride under mild conditions is described. The synthesis of the 4-aryl-1,2,3,4-tetrahydroisoquinoline alkaloid structures was accomplished via benzylic lithiation of N-methyl-3,4-dimethoxy-2-(4′-methoxybenzyl)benzamide.

Ruthenium Tetroxide Oxidation of N-Acylated Alkylamines: A New General Synthesis of Imides

Oxidation of various N-acylalkylamines with ruthenium tetroxide (RuO4) was systematically investigated.N-acylalkylamines having an electron-donating group at the α- or β-position with respect to amide nitrogen or an electron-donating alkyl function in the acyl group were smoothly oxidized to the corresponding imides in excellent yields.On the other hand, N-acylalkylamines having an electron-withdrawing group were not oxidized at all, and most of the starting material was recovered.It appears that the reactivity of N-acylalkylamines is closely correlated with the acidity of the carboxylic acid from which the N-acyl group is derived, and also with the electron density at the methylene moiety adjacent to the amide nitrogen atom.Keywords---oxidation; ruthenium tetroxide oxidation; imide synthesis; acyclic imide; amide; ruthenium tetroxide; substituent effect