111466-31-0Relevant articles and documents
STUDIES ON ASYMMETRIC SYNTHESIS OF β-HYDROXY-δ-LACTONE INHIBITORS OF HMGCoA REDUCTASE 1. A NEW PREPARATION OF THE LACTONE MOIETY OF COMPACTIN
Bonadies, Francesco,Fabio, Romano Di,Gubbiotti, Andreina,Mecozzi, Sandro,Bonini, Carlo
, p. 703 - 706 (2007/10/02)
A new strategy for the preparation of chiral β-hydroxy-δ-lactone inhibitors of HMGCoA reductase is outlined: in particular the compactin lactone moiety has been elaborated by asymmetric epoxidation of the appropriate allylic alcohol and subsequent introdu