111600-85-2

Basic information

• Product Name: Thiazole, 2-ethynyl-
• Synonyms: Thiazole, 2-ethynyl-;2-ethynylthiazole;2-ethynyl-1,3-thiazole
• CAS NO: 111600-85-2
• Molecular Formula: C₅H₃NS
• Molecular Weight: 109.15
• Mol File: 111600-85-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 183.6±23.0 °C(Predicted)
• Appearance: /
• Density: 1.21±0.1 g/cm3(Predicted)
• PKA: 1.09±0.10(Predicted)
• CAS DataBase Reference: Thiazole, 2-ethynyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiazole, 2-ethynyl-(111600-85-2)
• EPA Substance Registry System: Thiazole, 2-ethynyl-(111600-85-2)

Safety Data

• Hazardous Substances Data: 111600-85-2(Hazardous Substances Data)

Upstream product

• 3034-53-5 2-bromo-1,3-thiazole 
• 1066-54-2 trimethylsilylacetylene 
• 113705-15-0 2-(trimethyl-silylethynyl)-1,3-thiazole 

Downstream Products

• 1260025-23-7 C₁₉H₁₀ClFN₄S 
• 1071795-03-3 2-(4-bromo-phenylethynyl)-thiazole 

Relevant articles and documents

Synthesis and anti-inflammatory activity of ethynylthiazoles

A series of acetylene derivatives of thiazole using the Sonogashira cross-coupling method was synthesized and evaluated in vivo for their anti-inflammatory activity. Four compounds exhibited good anti-inflammatory activity and two inhibited soybean lipoxy

Design and characterization of a heterocyclic electrophilic fragment library for the discovery of cysteine-targeted covalent inhibitors

A fragment library of electrophilic small heterocycles was characterized through cysteine-reactivity and aqueous stability tests that suggested their potential as covalent warheads. The analysis of theoretical and experimental descriptors revealed correlations between the electronic properties of the heterocyclic cores and their reactivity against GSH that are helpful in identifying suitable fragments for cysteines with specific nucleophilicity. The most important advantage of these fragments is that they show only minimal structural differences from non-electrophilic counterparts. Therefore, they could be used effectively in the design of targeted covalent inhibitors with minimal influence on key non-covalent interactions.

(DIHYDRO)PYRROLO[2,1-A]ISOQUINOLINES

The invention relates to 5,6 - dihydropyrrolo [2,1-a] isoquinoline and pyrrolo[2,1-a] isoquinoline derivatives according to general formula (I) or a pharmaceutically acceptable salt thereof. The compounds can be used for the treatment of infertility.