111669-25-1

Basic information

• Product Name: 3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine
• Synonyms: 1-(TERT-BUTYLOXYCARBONYL)-4-(3-AMINOPYRIDIN-2-YL)PIPERAZINE;3-AMINO-2-[4-BUTOXYCARBONYL(PIPERAZINO)]PYRIDINE;BUTTPARK 46\04-67;tert-butyl 4-(3-aminopyridin-2-yl)piperazine-1-carboxylate;3-Amino-2-[4-tert-butoxycarbonyl(piperazino)]pyridine ,97%;3-Amino-2-[4-tert-butoxycarbonyl(piperazino)]pyridine;1-Boc-4-(3-aMinopyridin-2-yl)piperazine;butyl 4-(3-aminopyridin-2-yl)piperazine-1-carboxylate
• CAS NO: 111669-25-1
• Molecular Formula: C₁₄H₂₂N₄O₂
• Molecular Weight: 278.35
• EINECS: 200-528-9
• Product Categories: pharmacetical;Amines;Pyridines;Heterocycle-Pyridine series
• Mol File: 111669-25-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 448.8 °C at 760 mmHg
• Flash Point: 225.3 °C
• Appearance: /
• Density: 1.182 g/cm³
• Vapor Pressure: 3E-08mmHg at 25°C
• Refractive Index: 1.569
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 9.35±0.29(Predicted)
• CAS DataBase Reference: 3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine(111669-25-1)
• EPA Substance Registry System: 3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine(111669-25-1)

Safety Data

• Hazard Codes: T
• Statements: 25-36/37/38
• Safety Statements: 45-37-26
• Hazardous Substances Data: 111669-25-1(Hazardous Substances Data)

Usage

Chemical Properties

Grey to purple powder

InChI:InChI=1/C14H22N4O2/c1-14(2,3)20-13(19)18-9-7-17(8-10-18)12-11(15)5-4-6-16-12/h4-6H,7-10,15H2,1-3H3

Upstream product

• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 87394-48-7 1-(3-nitro-2-pyridinyl)piperazine 
• 5470-18-8 2-Chloro-3-nitropyridine 
• 153473-24-6 1-tert-butoxycarbonyl-4-(3-nitro-2-pyridyl)piperazine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 87394-62-5 1-(3-amino-pyridin-2-yl)-piperazine 

Downstream Products

• 136818-14-9 1-[1,1-Dimethylethoxycarbonyl]-4-[3-(1-methylethylamino)-2-pyridinyl]piperazine 
• 147539-20-6 1-[1,1-Dimethylethoxycarbonyl]-4-[3-(propylamino)-2-pyridinyl]piperazine 
• 136817-55-5 delavirdine 
• 1316754-35-4 2-(4-((1-benzyl-2-[⁽¹⁴⁾C]-imidazol-5-yl)methyl)piperazin-1-yl)-N-isopropylpyridin-3-amine 
• 1316754-32-1 2-(4-((1-benzyl-2-(methylthio)-2-[⁽¹⁴⁾C]-imidazol-5-yl)methyl)-piperazin-1-yl)-N-isopropylpyridin-3-amine 
• 1316754-33-2 1-(1-benzyl-2-[⁽¹⁴⁾C]-5-imidazoyl)-4-[3-(isopropylamino)-2-pyridyl]piperazine 
• 1316754-21-8 1-(1-benzyl-2-methylthio-2-[⁽¹⁴⁾C]-5-imidazoyl)-4-[3-(isopropylamino)-2-pyridyl]piperazine 
• 111669-24-0 4-[3-(Ethylamino)-2-pyridinyl]-piperazine 
• 403502-22-7 [2-chloro-5-(3-nitro-phenyl)-1H-pyrrol-3-yl]-[4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-methanone 
• 403502-21-6 [2-chloro-5-(4-nitro-phenyl)-1H-pyrrol-3-yl]-[4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-methanone 
• 403502-23-8 [2-chloro-5-(2-nitro-phenyl)-1H-pyrrol-3-yl]-[4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-methanone 
• 403502-17-0 [4-[3-(isopropylamino)-2-pyridyl]piperazino]-[5-(4-nitrophenyl)-1H-2-pyrrolyl]methanone 
• 403502-19-2 [4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-[5-(3-nitro-phenyl)-1H-pyrrol-2-yl]-methanone 
• 403502-46-5 [5-(4-amino-phenyl)-1H-pyrrol-3-yl]-[4-(3-isopropylamino-pyridin-2-yl)-piperazin-1-yl]-methanone 

Relevant articles and documents

Oligomer modified diaromatic substituted compounds

Disclosed are compounds comprising diaromatic substituted compound residues, namely the anti-viral (anti-HIV) drug delavirdine, covalently attached via a linkage to water-soluble, non-peptidic oligomers, specifically to poly(ethylene glycol) (PEG) oligome

Strategy for 14C-labeling of a series of bis(heteroaryl) piperazines

Four bis(heteroaryl)piperazines labeled with carbon-14 in the 2-position of imidazole moiety were prepared as part of a 4-step (or 5-step) sequence from 5-hydroxymethyl-2-mercapto-1-benzylimida-zole-[2-14C] as a key synthetic intermediate which

Synthesis and anti-HIV-1 activity of new delavirdine analogues carrying arylpyrrole moieties

In our search for novel anti-human immunodeficiency virus (HIV)-1 agents, 14 delavirdine analogues were synthesized and evaluated as potential anti-HIV-1 agents in cell-based assays. Compound 1Aa exhibited potent and selective anti-HIV-1 activity in acutely infected MT4 cells, with effective concentration (EC50) values in the submicromolar range.