1119-40-0Relevant articles and documents
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Schaafsma,S.E. et al.
, p. 827 - 830 (1973)
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Hagedorn III,Farnum
, p. 3765 (1977)
Straightforward synthesis of functionalized (E)-3-acylacrylic acids
Sivák, Ivan,Václav, Jakub,Berke?, Du?an,Kolarovi?, Andrej
, p. 8871 - 8875 (2015)
An experimentally simple, mild and straightforward synthetic route towards diversely functionalized (E)-3-acylacrylic acids is described, with Horner-Wadsworth-Emmons (HWE) reaction as the key step. The substrate scope and limitations of the HWE reaction were investigated with a range of β-ketophosphonates. Glyoxylic acid monohydrate was demonstrated to be fully compatible with the HWE reaction conditions, thus avoiding a troublesome hydrolysis of the corresponding 3-acylacrylates in the last step and providing a valuable synthetic shortcut.
Palladium-catalyzed selective generation of CO from formic acid for carbonylation of alkenes
Sang, Rui,Kucmierczyk, Peter,Dong, Kaiwu,Franke, Robert,Neumann, Helfried,Jackstell, Ralf,Beller, Matthias
supporting information, p. 5217 - 5223 (2018/04/24)
A general and selective palladium-catalyzed alkoxycarbonylation of all kinds of alkenes with formic acid (HCOOH, FA) is described. Terminal, di-, tri-, and tetra-substituted including functionalized olefins are converted into linear esters with high yields and regioselectivity. Key-to-success is the use of specific palladium catalysts containing ligands with built-in base, e.g., L5. Comparison experiments demonstrate that the active catalyst system not only facilitates isomerization and carbonylation of alkenes but also promotes the selective decomposition of HCOOH to CO under mild conditions.
Efficient and selective oxidation of aldehydes with dioxygen catalysed by vanadium-containing heteropolyanions
El Amrani, Ikram,Atlamsani, Ahmed,Dakkach, Mohamed,Rodríguez, Montserrat,Romero, Isabel,Amthiou, Souad
, p. 888 - 895 (2017/09/26)
The heteropolyacids “H3+n[PMo12–nVnO40]·aq” (denoted as HPA-n; n = 2, 3, 8) catalyse the oxidation of aldehydes to carboxylic acids in the presence of dioxygen with very good yields. The effect on the catalytic activity of various parameters such as the precursors, solvent, temperature or catalyst/substrate ratio was examined. The process is particularly selective for linear and aromatic aldehydes. The oxidation of adipaldehyde with dioxygen in mild conditions, in the presence of HPA-2 as a catalyst, leads to the formation of adipic acid together with a significant amount of other byproducts. Thus, several modifications of the catalytic systems have been carried out to improve their selectivity. The effect of cocatalysts was investigated and, among the species tested, complex Ni(acac)2 was found to be the most efficient yielding 60% of adipic acid.