112028-91-8

Basic information

• Product Name: Diphenylmethyl 7beta-Tert-Butoxycarbonylamino-3-Chloromethyl-3-Cephem-4-Carboxylate
• Synonyms: Diphenylmethyl 7beta-Tert-Butoxycarbonylamino-3-Chloromethyl-3-Cephem-4-Carboxylate;(6R,7R)-3-(Chloromethyl)-7-[[(tert-butoxy)carbonyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester;(6R,7R)-Benzhydryl 7-((tert-butoxycarbonyl)aMino)-3-(chloroMethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;(6R,7R)-Benzhydryl 7-((tert-butoxycarbonyl)amino)-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.;7β-tert-ButoxycarbonylaMino-3-chloroMethyl-3-cepheM- 4-carboxylate;(6R,7R)-3-(chloromethyl)-7-[[(1,1-dimethylethoxy)carbonyl]amino]-8-oxo-5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester;benzhydryl (6R,7R)-3-(chloromethyl)-7-[(2-methylpropan-2-yl)oxycarbonylamino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;(6R,7R)-Benzhydryl 7-((tert-butoxycarbonyl)amino)-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4
• CAS NO: 112028-91-8
• Molecular Formula: C₂₆H₂₇ClN₂O₅S
• Molecular Weight: 515.02098
• EINECS: 1312995-182-4
• Mol File: 112028-91-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 685.7±55.0 °C(Predicted)
• Appearance: /
• Density: 1.36
• Storage Temp.: 2-8°C
• PKA: 10.16±0.60(Predicted)
• CAS DataBase Reference: Diphenylmethyl 7beta-Tert-Butoxycarbonylamino-3-Chloromethyl-3-Cephem-4-Carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Diphenylmethyl 7beta-Tert-Butoxycarbonylamino-3-Chloromethyl-3-Cephem-4-Carboxylate(112028-91-8)
• EPA Substance Registry System: Diphenylmethyl 7beta-Tert-Butoxycarbonylamino-3-Chloromethyl-3-Cephem-4-Carboxylate(112028-91-8)

Safety Data

• Hazardous Substances Data: 112028-91-8(Hazardous Substances Data)

Usage

General Description

Diphenylmethyl 7beta-Tert-Butoxycarbonylamino-3-Chloromethyl-3-Cephem-4-Carboxylate is a complex chemical substance which is essentially an organic compound. It belongs to the family of Cephalosporins and Beta-lactams, which are a group of antibiotics derived from fungi. Its role is typically involved in pharmaceutical research and drug development, indicating its importance within the biotech and health industries. It represents a specific type of cephalosporin that is modified to possess a chloromethyl group and a carboxylate functional group, possibly suggesting its unique physiochemical properties and potential pharmacological activities. However, the details about its specific uses and properties are not widely available, indicating it may be used in more specialized research contexts.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 79349-53-4 (6R,7R)-7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxyli acid diphenylmethyl ester hydrochloride 
• 52312-27-3 (6R)-trans-3-(hydroxymethyl)-7-<<(1,1-dimethylethoxy)carbonyl>amino>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphenyl methyl ester 

Downstream Products

• 288379-38-4 diphenylmethyl 7β-tert-butoxycarbonylamino-3-(3-pyridyl)methylthiomethyl-3-cephem-4-carboxylate 
• 129849-27-0 (6R,7R)-3-But-3-enyl-7-tert-butoxycarbonylamino-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 288379-99-7 7β-[2-(Z)-(2-aminothiazol-4-yl)-2-(trityloxyimino)acetamido]-3-(4-pyridyl)thiomethyl-3-cephem-4-carboxylic acid 
• 288379-51-1 7β-[2-(Z)-(2-aminothiazol-4-yl)-2-(trityloxyimino)acetamido]-3-(3-pyridyl)thiomethyl-3-cephem-4-carboxylic acid 
• 199739-73-6 (6R,7R)-7-tert-Butoxycarbonylamino-3-(2,5-dichloro-phenylsulfanylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 129849-25-8 (2R,6R,7R)-2-Allyl-7-tert-butoxycarbonylamino-3-methylene-8-oxo-5-thia-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester 
• 129849-25-8 (2R,6S,7S)-2-Allyl-7-tert-butoxycarbonylamino-3-methylene-8-oxo-5-thia-1-aza-bicyclo[4.2.0]octane-2-carboxylic acid benzhydryl ester 

Relevant articles and documents

Ultrasonic-Assisted Synthesis of Two t -Butoxycarbonylamino Cephalosporin Intermediates on SiO2

Herein, we describe a facile and high efficient strategy for the synthesis of two forms of the 7β-t-butoxycarbonylamino-3-chloromethyl-3-cephem-4-carboxylates using ultrasonic irradiation. By SiO2 as weak Lewis acid catalyst, 4-methoxybenzyl 7β-t-butoxycarbonylamino-3-chloromethyl-3-cephem-carboxylate (Boc-ACLE) and benzhydryl 7β-t-butoxycarbonylamino-3-chloromethyl-3-cephem-4-carboxylate (Boc-ACLH) were successfully synthesized through the efficient protection of the N-t-butoxycarbonyl (N-Boc), and the reactions occurred at low temperature requiring short reaction times and exhibiting excellent isolated yields (96% and 96.2%, resp.). The advantages of this reaction route including the usage of economical reagents and mild reaction conditions and high isolated yield make the two significant t-butoxycarbonylamino cephalosporin intermediates possible in large-scale production.

Dual-action cephalosporins incorporating a 3'-tertiary-amine-linked quinolone

We have previously reported that linking quinolones to the cephalosporin 3'-position through an ester bond, a carbamate function, or a bond through a quaternary nitrogen produced cephalosporins with a dual mode of antibacterial action. We now describe a n