1121-91-1

Basic information

• Product Name: AMT HYDROCHLORIDE
• Synonyms: 4H-1,3-Thiazin-2-aMine,5,6-dihydro-6-Methyl-;2-AMINO-5,6-DIHYDRO-6-METHYL-4H-1,3-THIAZINE;2-AMINO-5,6-DIHYDRO-6-METHYL-4H-1,3-THIAZINE HCL;2-AMINO-5,6-DIHYDRO-6-METHYL-4H-1,3-THIAZINE HYDROCHLORIDE;5,6-DIHYDRO-6-METHYL-4H-1,3-THIAZIN-2-AMINE, HYDROCHLORIDE;AMT HYDROCHLORIDE;AMT;AMT HCL
• CAS NO: 1121-91-1
• Molecular Formula: C5H11ClN2S
• Molecular Weight: 166.67
• Mol File: 1121-91-1.mol
• Article Data: 2

Chemical Properties

• Melting Point: 146-150 °C
• Boiling Point: 236.126 °C at 760 mmHg
• Flash Point: 96.606 °C
• Appearance: /
• Density: 1.312 g/cm³
• Vapor Pressure: 0.0482mmHg at 25°C
• Storage Temp.: 2-8°C
• CAS DataBase Reference: AMT HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: AMT HYDROCHLORIDE(1121-91-1)
• EPA Substance Registry System: AMT HYDROCHLORIDE(1121-91-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 1121-91-1(Hazardous Substances Data)

Usage

General Description

AMT Hydrochloride, also known as Alpha-Methyltryptamine, is a synthetic compound of the tryptamine class. It is known for its psychedelic and stimulant effects. It has been popular as a recreational drug since the 1960s and was briefly marketed as an antidepressant under the brand name Indopan in the 1960s. However, due to potential risks associated with its misuse, it has been categorized as a Schedule I controlled substance in the United States. AMT Hydrochloride affects the body's serotonin system, altering mood, perception, and behavior.

InChI:InChI=1/C5H10N2S.ClH/c1-4-2-3-7-5(6)8-4;/h4H,2-3H2,1H3,(H2,6,7);1H

Upstream product

• 21463-49-0 3-chloro-1-isothiocyanato-butane 
• 89365-11-7 1-(3-butenyl)-2-thiourea 
• 21463-32-1 tert-butyl-(6-methyl-5,6-dihydro-4H-[1,3]thiazin-2-yl)-amine 

Relevant articles and documents

Novel potent and selective inhibitors of inducible nitric oxide synthase

We have identified two novel potent and selective inhibitors of inducible nitric oxide synthase, S-ethylisothiourea and 2-amino-5,6-dihydro-6-methyl- 4H-1,3-thiazine. K(i) values of 14.7 nM for S-ethylisothiourea and 4.2 nM for 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine were obtained with partially purified preparations of inducible nitric oxide synthase. These compounds demonstrate about 1000-fold greater potency than prototypical inhibitors, and the inhibitions are 10-40-fold more selective for murine inducible nitric oxide synthase, compared with the rat neuronal and bovine endothelial isoforms of nitric oxide synthase. These compounds also potently inhibit the nitric oxide synthase activity in intact J774 mouse macrophages. The inhibition is competitive with the substrate L-arginine and reversible in both enzymatic and intact cell assays. These potent and selective inhibitors of inducible nitric oxide synthase may have potential therapeutic applications in the treatment of inflammatory and autoimmune diseases.