112101-81-2Relevant articles and documents
NOVEL PROCESS FOR THE SYNTHESIS OF ENANTIOMERICALLY PURE 2-METHOXY-5-[(2R)-2-(4-ALKYLPIPERAZIN-L-YL)PROPYL]-BENZENESULFONAMIDE
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Page/Page column 7-8, (2012/08/08)
Where R is C1-C3 alkyl, alkenyl A novel process for synthesis of compound of Formula 1 comprising steroselective catalytic reduction of compound of Formula IV under hydrogen gas pressure to obtain an intermediate compound of Formula II, which on coupling in presence of coupling agent and base in presence of organic solvent to obtain compound of Formula X, Formula X on reacting with deprotecting agent in presence of organic solvent results in formation of compound of Formula XI, condensation of Formula XI with alkyl halide results in formation of compound of Formula I.
Improved process for the preparation of tamsulosin hydrochloride
Reddy, A. Veera,Bhaskara Rao, S. Udaya,Narasimha, G. Lakshmi,Dubey
experimental part, p. 1451 - 1456 (2009/09/25)
Ellman's sulfinamide reagent is used in asymmetric synthesis of Tamsulosin hydrochloride. The enantiomeric ratio achieved is 87:13. The crystallization of the same with dibenzoyl tartarate afforded the product 2 with 99.5% ee.
Assymetric formal synthesis of (-)-formoterol and (-)-tamsulosin
Kim, Yongeun,Kang, Lae-Sung,Ha, Hyun-Joon,Ko, Seung Whan,Lee, Won Koo
, p. 2243 - 2248 (2008/09/17)
Biologically important (2R)-2-amino-3-phenylpropanes consisted in commercial drugs including (R,R)-formoterol, and (R)-tamsulosin were prepared from chiral (2R)-aziridine-2-carboxylate without any chromatographic separation. Key reactions include regio- and stereoselective ring opening reaction of aziridin-2-yl-phenylmethanol and subsequent cyclization toward enantiopure 4,5-disubastitued oxazolidin-2-ones as synthetic intermediates.