112170-33-9

Basic information

• Product Name: Benzeneacetonitrile, 4-(4-pyridinyl)-
• CAS NO: 112170-33-9
• Molecular Formula: C13H10N2
• Molecular Weight: 194.236
• Mol File: 112170-33-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzeneacetonitrile, 4-(4-pyridinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetonitrile, 4-(4-pyridinyl)-(112170-33-9)
• EPA Substance Registry System: Benzeneacetonitrile, 4-(4-pyridinyl)-(112170-33-9)

Safety Data

• Hazardous Substances Data: 112170-33-9(Hazardous Substances Data)

Upstream product

• 19524-06-2 4-bromopyridine hydrochloride 
• 140-29-4 phenylacetonitrile 
• 16532-79-9 4-Bromophenylacetonitrile 
• 1692-15-5 4-pyridylboronic acid 

Downstream Products

• 950520-47-5 4,4'-di(4-pyridyl)cyanostilbene 

Relevant articles and documents

Ratio-dependent lysosome pH probe with aggregation-induced emission property and application thereof

The invention relates to a simple preparation method of illuminants (AIEgens) which are used for testing lysosome pH and have aggregation-induced luminescence (AIE). The ratio type pH probe can be used for testing the pH of which the maximum range is 3-6.5. The AIE illuminant can be used for quantitatively testing the pH value of lysosome in in-vitro cells, and also can be used for testing the pH value of lysosome in a small living fish. The AIE illuminant can also track the detailed change process of the average lysosome pH and the distribution condition of the lysosome pH in the regeneration process of the small fish tail fin for a long time, and a simple, convenient and effective method is provided for observing the regeneration process.

Red/near-infrared AIE probe and preparation method thereof, and application of red/near-infrared AIE probe in detection of Abeta aggregate and fibrotic plaques of Abeta aggregate

The invention belongs to the technical field of biological imaging, and relates to a red/near-infrared AIE probe, a preparation method thereof and an application of the red/near-infrared AIE probe indetection of Abeta aggregates and fibrotic plaques of the Abeta aggregates. The probe has a general formula, and the preparation method comprises the following steps: carrying out Suzuki reaction on bromine-substituted aryl acetonitrile and arylboronic acid, carrying out substitution or salification reaction on the reaction product and a straight-chain halogenated compound, and finally carrying out Knoevenagel condensation reaction on the reaction product and an aldehyde-substituted aromatic compound to obtain a target compound. Compared with the prior art, the aggregation-induced emission (AIE) probe disclosed by the invention overcomes the fluorescence quenching effect caused by aggregation, so that the AIE probe has higher luminous efficiency and signal-to-noise ratio. And the probe canrealize high-selectivity and high-sensitivity detection of the A beta aggregate. More importantly, the probe can realize early imaging of A beta fibrotic plaques in vivo.

A New Synthesis of Aryl Hetaryl Ketones via SRN1 Reaction of Halogenated Heterocycles withPotassiophenylacetonitrile Followed by Phase-Transfer Catalyzed Decyanation

Reaction of halogenated pyridines, quinolines, pyrimidines, and pyrazines with potassiophenylacetonitrile (5) in liquid ammonia under near-uv irradiation affords secondary nitriles, which then undergo oxidative decyanation under phase-transfer catalytic conditions to afford aryl hetaryl ketones in excellent yields.