1121978-98-0

Basic information

• Product Name: 2,4-bis(4-chlorobenzylidene)-8-methyl-8-aza-bicyclo[3.2.1]octan-3-one
• Synonyms: 2,4-bis(4-chlorobenzylidene)-8-methyl-8-aza-bicyclo[3.2.1]octan-3-one
• CAS NO: 1121978-98-0
• Molecular Weight: 384.305
• Mol File: 1121978-98-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,4-bis(4-chlorobenzylidene)-8-methyl-8-aza-bicyclo[3.2.1]octan-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-bis(4-chlorobenzylidene)-8-methyl-8-aza-bicyclo[3.2.1]octan-3-one(1121978-98-0)
• EPA Substance Registry System: 2,4-bis(4-chlorobenzylidene)-8-methyl-8-aza-bicyclo[3.2.1]octan-3-one(1121978-98-0)

Safety Data

• Hazardous Substances Data: 1121978-98-0(Hazardous Substances Data)

Upstream product

• 532-24-1 tropinone 
• 104-88-1 4-chlorobenzaldehyde 

Relevant articles and documents

The cytotoxic properties and preferential toxicity to tumour cells displayed by some 2,4-bis(benzylidene)-8-methyl-8-azabicyclo[3.2.1] octan-3-ones and 3,5-bis(benzylidene)-1-methyl-4-piperidones

This study demonstrated that replacement of the axial protons on the C2 and C6 atoms of various 1-methyl-3,5-bis(benzylidene)-4-piperidones 3 by a dimethylene bridge leading to series 2 lowered cytotoxic potencies. Four compounds 2a and 3a-c emerged as lead molecules based on their toxicity towards different neoplasms and their selective toxicity for malignant rather than normal cells. Some possible reasons for the disparity between the IC50 values in the two series of compounds are presented based on molecular modeling, log P values and respiration in rat liver mitochondria.