1122-71-0

Basic information

• Product Name: 6-METHYL-2-PYRIDINEMETHANOL
• Synonyms: 6-methyl-2-pyridylmethanol;2-Methyl-6-pyridinemethanol;6-METHYL-2-PYRIDINEMETHANOL 98%;6-methyl-2-pyridinemthanol;6-METHYL-2-PYRIDINEMETHANOL 95+%;2-Methylpyridine-6-methanol;6-METHYL-2-PYRIDINEM;2-Hydroxymethyl-6-methylpyridine 6-Hydroxymethyl-2-picoline
• CAS NO: 1122-71-0
• Molecular Formula: C₇H₉NO
• Molecular Weight: 123.15
• EINECS: 214-358-2
• Product Categories: C7 and C8;Heterocyclic Building Blocks;Pyridines;pyrdine series;alcohol
• Mol File: 1122-71-0.mol
• Article Data: 22

Chemical Properties

• Melting Point: 32-34 °C(lit.)
• Boiling Point: 105-108 °C12 mm Hg(lit.)
• Flash Point: 228 °F
• Appearance: Clear light brown liquid or low melting solid
• Density: 1.0877 (rough estimate)
• Vapor Pressure: 0.0883mmHg at 25°C
• Refractive Index: 1.5380 (estimate)
• Storage Temp.: Refrigerator
• PKA: 14.02±0.10(Predicted)
• Water Solubility: Low soluble in water, high soluble in ethanol, acetic acid. Soluble in benzene, toluene.
• CAS DataBase Reference: 6-METHYL-2-PYRIDINEMETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 6-METHYL-2-PYRIDINEMETHANOL(1122-71-0)
• EPA Substance Registry System: 6-METHYL-2-PYRIDINEMETHANOL(1122-71-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36-37/39-36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 1122-71-0(Hazardous Substances Data)

Usage

Description

6-Methyl-2-pyridinemethanol, also known as 6-Methyl-2-(hydroxymethyl)pyridine, is an organic compound that belongs to the pyridine family. It is characterized by a clear light brown color and can exist as a liquid or low melting solid. This versatile compound serves as a primary and secondary intermediate in the synthesis of various chemical products.

Uses

Used in Pharmaceutical Industry:
6-Methyl-2-pyridinemethanol is used as a primary and secondary intermediate for the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be a key component in the development of new drugs and medications, contributing to the advancement of medical treatments.
Used in Chemical Synthesis:
In the field of chemical synthesis, 6-Methyl-2-pyridinemethanol is utilized as an intermediate for the production of a wide range of chemical products. Its versatility and reactivity make it a valuable building block in the creation of various compounds, including those used in the fragrance, agrochemical, and specialty chemical industries.
Used in Research and Development:
6-Methyl-2-pyridinemethanol is also employed in research and development settings, where it is used to study the properties and behavior of pyridine-based compounds. This knowledge can be applied to the design and development of new materials and products, further expanding the potential applications of this versatile intermediate.

InChI:InChI=1/C7H9NO/c1-6-3-2-4-7(5-9)8-6/h2-4,9H,5H2,1H3

Upstream product

• 13602-11-4 6-methylpicolinic acid methyl ester 
• 1122-72-1 6-methyl-2-pyridinecarboxaldehyde 
• 1073-23-0 2,6-lutidine N-oxide 
• 67-56-1 methanol 
• 116600-45-4 1,2-Dimethoxy-pyridinium-methylsulfat 
• 591-78-6 n-hexan-2-one 
• 13287-64-4 acetic acid 6-methyl-pyridin-2-ylmethyl ester 
• 75-36-5 acetyl chloride 
• 108-48-5 2,6-dimethylpyridine 
• 1195-59-1 2.6-bis(hydroxymethyl)pyridine 
• 931-19-1 2-methylpyridine N-oxide 
• 78539-91-0 7-methyl-1,2,3-triazolo<1,5-a>pyridine 

Downstream Products

• 13287-64-4 acetic acid 6-methyl-pyridin-2-ylmethyl ester 
• 1122-72-1 6-methyl-2-pyridinecarboxaldehyde 
• 3099-29-4 2-(chloromethyl)-6-methylpyridine 
• 3400-78-0 2-hydroxy-3-methyl-2-cyclohexen-1-one 
• 76320-22-4 3-(hydroxymethyl)cyclohex-2-en-1-one 
• 790235-44-8 N-(6-methyl-pyridin-2-ylmethyl)-4-nitro-N-pyridin-2-ylmethyl-benzenesulfonamide 
• 7252-50-8 2-hydroxy-[1,2-bis(6-methylpyridin-2-yl)]ethan-1-one 
• 6630-11-1 1,2-bis(6-methylpyridin-2-yl)ethane-1,2-dione 
• 131339-20-3 1-(pyridin-2-yl)-2-(6-methylpyridin-2-yl)ethane-1,2-dione 
• 934-60-1 6-methyl-2-pyridinecarboxylic acid 
• 866588-10-5 methyl 4-({3-tert-butyl-5-[(6-methylpyridin-2-yl)methoxy]-1H-pyrazol-1-yl}methyl)benzoate 
• 676361-01-6 N₂-(3-chloro-4-methoxyphenyl)-N₄-cycloheptyl-6-(6-methyl-pyridin-2-ylmethoxy)-1,3,5-triazine-4,2-diamine 
• 1191923-31-5 N-[(1S)-1-cyclohexyl-2-(methylamino)-2-oxoethyl]-5-{5-[(6-methylpyridin-2-yl)methoxy]pyridin-2-yl}furan-2-carboxamide 
• 1221072-78-1 2,6-diisopropyl-N-((6-methylpyridin-2-yl)methyl)benzenamine 

Relevant articles and documents

SEQUENCE OF REPLACEMENT OF HYDROGEN IN 2,6-DIMETHYLPYRIDINE BY LITHIUM OR HALOGEN

It is shown that, according to the results of chromatographic mass spectrometry, the reaction of 2,6-dimethylpyridine with phenyllithium leads only to the monolithium derivative.The chlorination and bromination of 2,6-dimethylpyridine with various reagents were studied systematically.A method for the conversion of 2,6-bis(chloromethyl)pyridine to 2,6-bis(hydroxymethyl)pyridine is given.

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IMPROVED PROCEDURES FOR PREPARATION OF 2-PYRIDONES AND 2-HYDROXYMETHYLPYRIDINES FROM PYRIDINE N-OXIDES

2-Pyridones and 2-hydroxymethylpyridines were prepared from pyridine N-oxides by treatment with trifluoroacetic anhydride in dimethylformamide.The reaction proceeds at room temperature in satisfactory yields.

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ANALOGS OF 2-PRALIDOXIME AS ANTIDOTES AGAINST ORGANOPHOSPHORUS NERVE AGENTS

Provided herein are compounds useful in treating exposure to an organophosphorus compound, such as a nerve agent, pesticide, or, generally, an acetylcholinesterase inhibitor, such as sarin. Compositions, e.g. pharmaceutical compositions or dosage forms, comprising the compounds also are provided herein. Methods of treating a patient exposed to a nerve agent, pesticide, or, generally, an acetylcholinesterase inhibitor, e.g., an organophosphorus compound, such as sarin, also are provided.

Photochemical C-H Silylation and Hydroxymethylation of Pyridines and Related Structures: Synthetic Scope and Mechanisms

Considering the synthetic relevance of heteroarenes in various areas ranging from organic synthesis to medicinal chemistry, developing practically simple methodologies to access functionalized heteroarenes is of a significant value. Described herein is an efficient approach for C-H silylation and hydroxymethylation of pyridines and related heterocycles by the combination of silanes or methanol with readily available N-methoxypyridinium ions with a low catalyst loading (2 mol %) under blue light irradiation. The synthetic importance of the developed reactions is demonstrated by the synthesis of biologically relevant compounds. Electron paramagnetic resonance spectroscopy, quantum yield measurements, and density-functional theory calculations allowed us to understand reaction mechanisms of both photocatalytic reactions.