112228-65-6 Usage
Description
B220, also known as CD220, is a protein that is expressed on the surface of B cells, a type of white blood cell that plays a crucial role in the immune system. It is involved in the regulation of B cell activation, proliferation, and differentiation. B220 has been identified as a potential target for antiviral therapy due to its role in the immune response against viral infections.
Uses
Used in Antiviral Applications:
B220 is used as an antiviral agent for inhibiting the growth of various viruses, including herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), and human cytomegalovirus (CMV). Its antiviral properties make it a promising candidate for the development of new therapeutic strategies to combat viral infections.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, B220 is being investigated for its potential use in the development of antiviral drugs and therapies. Researchers are exploring ways to harness the antiviral properties of B220 to create new treatments for viral infections, particularly those caused by HSV-1, HSV-2, and CMV.
Used in Immunology Research:
B220 is also used in immunology research to study the role of B cells in the immune system and their interactions with other immune cells. Understanding the function of B220 and its role in B cell regulation can provide valuable insights into the development of new immunotherapies and vaccines for various diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 112228-65-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,2,2,2 and 8 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 112228-65:
(8*1)+(7*1)+(6*2)+(5*2)+(4*2)+(3*8)+(2*6)+(1*5)=86
86 % 10 = 6
So 112228-65-6 is a valid CAS Registry Number.
InChI:InChI=1/C20H22N4/c1-13-11-16-17(12-14(13)2)22-20-19(21-16)15-7-5-6-8-18(15)24(20)10-9-23(3)4/h5-8,11-12H,9-10H2,1-4H3
112228-65-6Relevant articles and documents
Interactions of antiviral indolo[2,3-b]quinoxaline derivatives with DNA
Wilhelmsson, L. Marcus,Kingi, Ngarita,Bergman, Jan
, p. 7744 - 7750 (2008)
Here, we present the synthesis of five novel indoloquinoxaline derivatives and investigate the DNA binding properties of these monomeric as well as dimeric compounds using absorption, fluorescence, and linear dichroism. Several of the mono- and dicationic derivatives presented have previously demonstrated an excellent antiviral effect that is higher than already acknowledged agents against human cytomegalovirus (CMV), herpes simplex virus type 1 (HSV-1), and varicella-zoster virus (VZV). We find that the DNA binding constants of the monomeric and dimeric derivatives are high (～106) and very high (～109), respectively. Results from the spectroscopic measurements show that the planar aromatic indoloquinoxaline moieties upon interaction with DNA intercalate between the nucleobases. Furthermore, we use poly(dAdT) 2 and calf thymus DNA in a competitive binding experiment to show that all our derivatives have an AT-region preference. The findings are important in the understanding of the antiviral effect of these derivatives and give invaluable information for the future optimization of the DNA binding properties of this kind of drugs.
