112243-88-6

Basic information

• Product Name: D-Proline, 1-[(2R)-3-mercapto-2-methyl-1-oxopropyl]-
• CAS NO: 112243-88-6
• Molecular Formula: C9H15NO3S
• Molecular Weight: 217.289
• Mol File: 112243-88-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: D-Proline, 1-[(2R)-3-mercapto-2-methyl-1-oxopropyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: D-Proline, 1-[(2R)-3-mercapto-2-methyl-1-oxopropyl]-(112243-88-6)
• EPA Substance Registry System: D-Proline, 1-[(2R)-3-mercapto-2-methyl-1-oxopropyl]-(112243-88-6)

Safety Data

• Hazardous Substances Data: 112243-88-6(Hazardous Substances Data)

Upstream product

• 78825-16-8 1-(3-mercapto-2-D-methyl-1-oxopropyl)-L-proline 
• 7440-66-6 zinc 

Downstream Products

• 75479-46-8 (S)-1-[3-((R)-2-Amino-2-carboxy-ethyldisulfanyl)-2-methyl-propionyl]-pyrrolidine-2-carboxylic acid 
• 78636-31-4 C₁₄H₂₂N₂O₆S₂ 
• 460-19-5 ethanedinitrile 
• 64838-57-9 captopril disulfide 
• 78636-28-9 (S)-1-(3-Methanesulfinyl-2-methyl-propionyl)-pyrrolidine-2-carboxylic acid 
• 78636-29-0 (S)-1-(2-Methyl-3-methylsulfanyl-propionyl)-pyrrolidine-2-carboxylic acid 
• 77083-32-0 (S)-1-{3-[2-(4-Bromo-phenyl)-2-oxo-ethylsulfanyl]-2-methyl-propionyl}-pyrrolidine-2-carboxylic acid 
• 128960-77-0 glutathione 
• 78636-30-3 captopril-glutathione mixed disulfide 
• 77083-33-1 (S)-1-{3-[1-(4-Dimethylamino-3,5-dinitro-phenyl)-2,5-dioxo-pyrrolidin-3-ylsulfanyl]-2-methyl-propionyl}-pyrrolidine-2-carboxylic acid 

Relevant articles and documents

Process for preparation of optically active N-mercaptoalkanoylamino acids

A process is disclosed wherein an optically active N-mercaptoalkanoylamino acid is prepared by (1) reacting an optically active β-hydroxyalkanoic acid, with a halogenating reagent to prepare an optically active β-haloalkanoyl halide (2) reacting the β-haloalkanoyl halide with an amino acid to produce an optically active N-β-haloalkanoylamino acid and (3) reacting the N-β-haloalkanoylamino acid with a reagent capable of converting the halogen into the thiol group, the configuration of the formulas (II), (III), (IV), (V), and (VI) being retained in all the optically active compounds throughout the process to prepare the compound represented by formula (I). The product of the present invention, for example, N-(3-mercapto-2-D-methylpropanoyl)-L-proline inhibits the enzymatic conversion of angiotensin I into angiotensin II and therefore is useful for relieving angiotensin-related hypertension.

Urinary metabolites of 1-(3-mercapto-2-D-methyl-1-oxopropyl)-L-proline (SQ-14225), a new antihypertensive agent, in rats and dogs

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