112410-23-8 Usage
General Description
Tebufenozide is an ecdysone insecticide, which causes the premature molting of insects by interfering with the normal development of insects. It has high insecticidal activity and high selectivity, being effective in treatment of all lepidopteran larvae, caterpillar, diamondback moth and beet armyworm. It has a strong ovicidal activity, being safe to non-target organisms. Tebfenozide has no irritating effect on the eyes and skin without any teratogenic, carcinogenic and mutagenic effects on higher animals, being of high safety to mammals, birds and natural enemies. It is an ideal insecticide during integrated control.
Chemical Properties
Pure white powder, melting point 191 ℃. Slightly soluble in water and organic solvents; stable to light. It is stable at 5 ° C in pH 7 aqueous solution upon light emission.
Toxicity (to higher animals)
Low toxicity
Mechanism of Action
Tebufenozide is a pro-skinning compound that selectively controls lepidopteran larvae by acting in close association with the descorticophilin receptor protein. During its effect, tebufenozide mimics the action of natural insect pest hormone 20-hydroxy-descorticoid, leading to its premature, deadly peeling.
Control object and using method
It can be used to control a variety of lettuce larvae such as cabbage, apples and other crops. It is effective in the treatment of all instar larvae at drug interval of 14d.
Control Spodoptera exigua, Spodoptera litura, Spodoptera frugiperda, melon field borer and cabbage budworm; apply in the early larvae emergence, spray 1 500 ~ 2 000 times 20% SC.
Control apple leaf roller and peach moth worm, Spray 1000 ~ 2000 times 20% suspension.
Control corn borer and bean curl moth; spray 1000 ~ 2000 times 20% suspension.
Attention
This product is toxic to silkworms, should pay attention to be away from the silkworm area.
This product is generally effective against Plutella xylostella and can be mixed with avermectin.
Spray uniformly; ensure that the contact of liquid with parasites.
It is best to apply pesticide in the evening when controlling beet armyworm.
Uses
Different sources of media describe the Uses of 112410-23-8 differently. You can refer to the following data:
1. Tebufenozide is used to control lepidopterous larvae on rice, fruit,
row crops, nut crops, vegetables and vines and in forestry.
2. Synthetic nonsteroidal ecdysone agonist causing premature molting; novel insect growth regulator specific to lepidopteran species. Insecticide.
Definition
ChEBI: A carbohydrazide that is hydrazine in which the amino hydrogens have been replaced by tert-butyl, 3,5-dimethylbenzoyl and 4-ethylbenzoyl groups respectively. It is an insecticide used widely against caterpillars.
Hazard
Low toxicity by ingestion, inhalation, and
skin contact.
Agricultural Uses
Insecticide, Insect growth regulator: Tebufenozide is an insect growth regulator that interferes
with molting of Lepidopteran larvae. It is used on
fruitworm, fireworms, false armyworm, gypsy moth, and
spanworms, and is applied pre-harvest. Registered for use
in EU countries. Registered for use in the U.S.
Trade name
CONFIRM?; MIMIC?; RH-5992?
Metabolic pathway
Oxidation of ethyl and methyl substituents of the phenyl rings of
tebufenozide occurs in soils and plants, to give carboxylic acids, alcohols
and a ketone.
Degradation
Tebufenozide was stable at 94 °C for 7 days, stable to light in pH 7
aqueous solution (25 °C) and stable in dark sterile water for 30 days
(25 °C). The DT50 in natural pond water, in light, was 30 days (25 °C)
(PM). It was stable in acidic and neutral buffer solutions. Hydrolysis
was marked in alkaline conditions (DT50 203 days, pH 10, 20°C).
Tebufenozide was stable in sterilised stream water in the dark but
degraded in non-sterile water (DT50 181 days). The insecticide was
photodegraded by sunlight (DT50 83 hours, summer 46°N). The
results suggest that microbial degradation and photolysis will be the
main routes of tebufenozide dissipation in natural aquatic conditions
(Sundaram, 1994).
Check Digit Verification of cas no
The CAS Registry Mumber 112410-23-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,2,4,1 and 0 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 112410-23:
(8*1)+(7*1)+(6*2)+(5*4)+(4*1)+(3*0)+(2*2)+(1*3)=58
58 % 10 = 8
So 112410-23-8 is a valid CAS Registry Number.
InChI:InChI=1/C22H28N2O2/c1-7-17-8-10-18(11-9-17)20(25)23-24(22(4,5)6)21(26)19-13-15(2)12-16(3)14-19/h8-14H,7H2,1-6H3,(H,23,25)
112410-23-8Relevant articles and documents
Molting hormonal and larvicidal activities of aliphatic acyl analogs of dibenzoylhydrazine insecticides
Shimizu, Bun-Ichi,Nakagawa, Yoshiaki,Hattori, Kazunari,Nishimura, Keiichiro,Kurihara, Norio,Ueno, Tamio
, p. 638 - 642 (1997)
Dibenzoylhydrazines are the nonsteroidal ecdysone agonists. Using comparative molecular field analysis, we previously found that the alkyl side chain of 20-hydroxyecdysone (20E) is three-dimensionally superposable with one of their two aryl moieties. To identify the aryl moiety that is better superposable on the alkyl chain, we synthesized compounds in which one of the two aryl groups of tebufenozide (N-t-butyl-N-3,5-dimethylbenzoyl-N'-4- ethylbenzoylhydrazine) is replaced by alkyl groups such as C4H9, C5H11, and C6H13. The molting hormonal activity of these compounds was measured using cultured integuments prepared from rice stem borers, Chilo suppressalis Walker, in terms of stimulation of incorporation of N:acetyl- [14C]glucosamine. N-t-Butyl-N-3,5-dimethylbenzoyl-N'-acylhydrazines with a hexanoyl or heptanoyl group were about 20-fold higher than that of 20E, whereas N-acyl-N-t-butyl-N'-4-ethylbenzoylhydrazines with a hexanoyl or heptanoyl group were much weaker than 20E. Their larvicidal activity was also measured against rice stem borers. The former series of compounds were much more active than the other series as well as 20E. Thus, the benzoyl moiety of dibenzoylhydrazines, which is bound to the secondary nitrogen atom (-NH-), is replaceable by aliphatic acyl groups without, greatly, affecting the biological activities.
Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
-
Page/Page column 5, (2008/06/13)
The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.
Insecticidal combination to control mammal fleas, in particular fleas on cats and dogs
-
, (2008/06/13)
Process and composition, in particular for controlling fleas on small mammals, characterized in that the composition includes, on the one hand, at least one insecticide of 1-N-arylpyrazole type, in particular fipronil, and, on the other hand, at least one compound of IGR (insect growth regulator) type, in doses and proportions which are parasiticidally effective on fleas, in a fluid vehicle which is acceptable for the animal and convenient for local application to the skin, preferably localized over a small surface area.
