112636-83-6 Usage
Description
Dicyclanil is an insect growth regulator belonging to the group of pyrimidinamines.Dicyclanil is a pyrimidin derivative. Dicyclanil is an insect development inhibitor very specific for the prevention of blowfly strike in sheep. It does not control any other external parasites of sheep. It is used mainly as a spray-on. It is not used in other livestock, horses or pets.
Uses
Dicyclanil is a veterinary medication for the protection against early season myiasis.
Application
Dicyclanil may be used as an analytical reference standard for the quantification of the analyte in biological samples, bovine, porcine and chicken muscle using various chromatography techniques.
Pharmacokinetics
Dicyclanil has a long lasting action which interferes with moulting and pupation in dipteran species. However, the precise mode of action of this compound on ectoparasites is not known. A variety of in vitro and in vivo pharmacodymanic tests were performed with dicyclanil in rats, mice and guinea pigs. In vitro, dicyclanil was devoid of significant effects on the neuromuscular junction at concentrations below 3 mM. Slight antagonistic effects on smooth muscle were reported at concentration levels above 0.1 mM. Dicyclanil caused a statistically significant increase in heart rate, tidal volume and minute volume at a dose level of 100 mg/kg bw in studies on the cardiovascular and respiratory systems in the rat. In various in vivo studies, dicyclanil was devoid of significant effects on behavior at a dose level of 1 mg/kg bw in mice.
Toxicity evaluation
Dicyclanil was investigated in a series of acute toxicity studies. The acute LD50 by the oral route in the rat was 520 mg/kg bw. The acute LD50 by the dermal route was greater than 2000 mg/kg bw in the rat. An acute inhalation toxicity study also conducted in the rat showed the acute LC50 to be 3,184 mg/m3 of air. The toxic effects were dyspnoea and reduced locomotor activity.
Check Digit Verification of cas no
The CAS Registry Mumber 112636-83-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,2,6,3 and 6 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 112636-83:
(8*1)+(7*1)+(6*2)+(5*6)+(4*3)+(3*6)+(2*8)+(1*3)=106
106 % 10 = 6
So 112636-83-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H10N6/c9-3-5-6(10)13-8(14-7(5)11)12-4-1-2-4/h4H,1-2H2,(H5,10,11,12,13,14)
112636-83-6Relevant articles and documents
Synthetic method of dicyclanil
-
Paragraph 0041; 0052-0056; 0060; 0065-0066; 0070; 0075-0076, (2020/05/01)
The invention discloses a synthetic method of dicyclanil. The sodium dicyandiamide and malononitrile are used as initial raw materials, a crude dicyandiamide product is obtained through condensation,cyclization and amination reactions, and a refined dicyandiamide product is obtained through decoloration and refining. The synthetic route is short, the process is green and environment-friendly, andmethyl mercaptan is not generated; the method has the advantages of mild reaction conditions, no need of pressurized ammonification, low equipment requirements and simple operation, and is suitable for domestic industrial production. The total yield reaches 65% or above, and the product purity reaches 99% or above.
A preparation method of ground past Neil
-
Paragraph 0013; 0041, (2017/04/25)
The invention discloses a preparation method of dicyclanil, belongs to the field of preparation of growth regulators, and solves the problem that the existing dicyclanil production process is high in synthetic condition, great in toxicity of synthetic raw materials and low in reaction yield. The preparation method comprises the following steps: carrying out substitution reaction on guanidine hydrochloride and bromocyclopropane; carrying out closed-ring reaction on the product obtained from the former step and 2-fluoropropiondiamide; and finally substituting florine on aromatic rings by providing cyan groups from potassium ferrocyanide to obtain a dicyclanil product. The preparation method disclosed by the invention is simple in operating step, low in price of materials and high in yield, and the obtained product is high in purity and shallow in color, and dicyanomethane which is relatively great in toxicity is not used in the production process.
