112769-53-6Relevant articles and documents
Synthesis of Novel Cyclic Sulfone Dihydropyridines Facilitated by a Selective Ethyl Diazoacetate Ring Expansion
Dodd, John H.,Schwender, Charles F.,Gray-Nunez, Yolanda
, p. 1453 - 1456 (2007/10/02)
A series of novel cyclic sulfone dihydropyridines with five to nine membered rings have been synthesized.Anomalous intermediates isolated from the Hantzch condensation were found to vary depending on the sulfone ring size and aromatic substitution.Tin tetrachloride has been shown to be a superior Lewis acid catalyst for ethyl diazoacetate ring expansion of the requisite β-keto cyclic sulfone precursors.
PHARMACEUTICALLY USEFUL SUBSTITUTED THIACYCLOALKENO [3,2-B]PYRIDINES, COMPOSITIONS AND METHOD OF USE
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, (2008/06/13)
Novel substituted thiacycloalkeno [3,2-b]pyridines are described. These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibronchoconstrictor activity.