1128-56-9

Basic information

• Product Name: 1-Phenyl-3-aminopyrazole
• Synonyms: 1-Phenyl-3-aminopyrazole;1-Phenyl-1H-pyrazol-3-ylamine;1H-Pyrazol-3-amine, 1-phenyl-;1-phenylpyrazol-3-amine;(1-phenylpyrazol-3-yl)amine;1-phenyl-3-pyrazolamine
• CAS NO: 1128-56-9
• Molecular Formula: C₉H₉N₃
• Molecular Weight: 159.19
• Product Categories: Heterocycles
• Mol File: 1128-56-9.mol
• Article Data: 18

Chemical Properties

• Melting Point: 101 °C
• Boiling Point: 323.2 °C at 760 mmHg
• Flash Point: 149.2 °C
• Appearance: /
• Density: 1.2 g/cm³
• Vapor Pressure: 0.000267mmHg at 25°C
• Refractive Index: 1.641
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 3.66±0.10(Predicted)
• CAS DataBase Reference: 1-Phenyl-3-aminopyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Phenyl-3-aminopyrazole(1128-56-9)
• EPA Substance Registry System: 1-Phenyl-3-aminopyrazole(1128-56-9)

Safety Data

• Hazardous Substances Data: 1128-56-9(Hazardous Substances Data)

Usage

General Description

1-Phenyl-3-aminopyrazole is an organic compound with the chemical formula C10H9N3. It is a derivative of pyrazole and contains a phenyl group and an amino group attached to the pyrazole ring. 1-Phenyl-3-aminopyrazole has potential applications in the field of medicinal chemistry, particularly as a building block for the synthesis of various pharmaceuticals and bioactive molecules. It may also have uses in the development of new materials and chemical processes. Its properties and potential uses make 1-Phenyl-3-aminopyrazole a subject of interest in scientific research and chemical synthesis.

InChI:InChI=1/C9H9N3/c10-9-6-7-12(11-9)8-4-2-1-3-5-8/h1-7H,(H2,10,11)

Upstream product

• 3314-35-0 3-Amino-1-phenyl-2-pyrazoline 
• 591-50-4 iodobenzene 
• 1820-80-0 3-aminopyrazole 
• 108-86-1 bromobenzene 
• 27412-65-3 3-nitro-1-phenyl-1H-pyrazole 
• 98-80-6 phenylboronic acid 
• 60838-50-8 3-methoxy-2-propenenitrile 
• 59-88-1 phenylhydrazine hydrochloride 
• 7732-18-5 water 
• 100-63-0 phenylhydrazine 
• 61310-53-0 3-ethoxyacrylonitrile 
• 458561-89-2 1-phenyl-1H-pyrazole-3-carbonyl azide 
• 509077-92-3 1-phenyl-1H-pyrazole-3-carboxylic acid hydrazide 
• 4747-46-0 1-phenyl-1H-pyrazole-3-carboxylic acid 

Downstream Products

• 88569-93-1 5-chloromethyl-1-phenyl-1H,7H-pyrazolo<1,5-a>pyrimidine-7-one 
• 17436-80-5 6,7-Dihydro-4-methyl-6-oxo-2-phenyl-pyrazolo<3,4-b>pyridin 
• 64748-64-7 1,5-diphenyl-1H-pyrazolo[1,5-a]pyrimidin-7-one 
• 71998-98-6 1-phenyl-3-(4-dimethylaminophenylazo)pyrazole 
• 92133-80-7 4-Methyl-N-(1-phenyl-1H-pyrazol-3-yl)-benzenesulfonamide 
• 87949-09-5 N-(1-phenyl-1H-pyrazol-3-yl)aminomethylenemalonic acid, diethyl ester 
• 127107-30-6 3-amino-1-phenylpyrazole hydrochloride 
• 425644-15-1 N-(1-phenylpyrazol-3-yl)-N-(1-benzyl-4-piperidyl)amine 
• 425644-16-2 N-(1-phenylpyrazol-3-yl)-N-(1-phenethyl-4-piperidyl)amine 
• 1006707-95-4 N-(1-phenylpyrazole-3-yl)-4-t-butylaniline 
• 1006707-97-6 N-(1-phenylpyrazole-3-yl)-N-(1-phenyl-1H-indazole-3-yl)-4-t-butylaniline 
• 1006707-98-7 3-(1-phenylpyrazole-3-yl)amino-1-phenyl-5-methylpyrazole 
• 328232-93-5 trans-3-oxo-N-(1-phenyl-1H-pyrazol-3-yl)-3H-spiro[6-aza-2-benzofuran-1,1'-cyclohexane]-4'-carboxamide 
• 328232-90-2 trans-3-oxo-N-(1-phenyl-1H-pyrazol-3-yl)-3H-spiro[4-aza-2-benzofuran-1,1'-cyclohexane]-4'-carboxamide 

Relevant articles and documents

Copper-Catalyzed N1 Coupling of 3-Aminoindazoles and Related Aminoazoles with Aryl Bromides

The N1-selective arylation of 3-aminoindazoles using copper catalysis is herein reported. The reaction uses readily accessible aryl bromides as coupling partners, including those from heterocycles, and allows easy access to a broad variety of substituted 3-aminoindazoles. The methodology was also examined on other aminoazoles of interest for the pharmaceutical industry.

COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY

This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.

HETEROCYCLIC COMPOUNDS AND USE OF SAME

Novel heterocyclic compounds are provided which display useful efficacy in the treatment of diseases caused by trypanosomatids. Particularly, the compounds of the invention are useful in the treatment of HAT and/or Chagas disease and/or Animal African trypanosomiasis (AAT).