112885-34-4

Basic information

• Product Name: 4-acetylamino-5-chloro-2-ethoxy-N-[[4-(4-fluorobenzyl)-2-morpholinyl]methyl]benzamide
• Synonyms: 4-acetylamino-5-chloro-2-ethoxy-N-[[4-(4-fluorobenzyl)-2-morpholinyl]methyl]benzamide
• CAS NO: 112885-34-4
• Molecular Weight: 463.936
• Mol File: 112885-34-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-acetylamino-5-chloro-2-ethoxy-N-[[4-(4-fluorobenzyl)-2-morpholinyl]methyl]benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-acetylamino-5-chloro-2-ethoxy-N-[[4-(4-fluorobenzyl)-2-morpholinyl]methyl]benzamide(112885-34-4)
• EPA Substance Registry System: 4-acetylamino-5-chloro-2-ethoxy-N-[[4-(4-fluorobenzyl)-2-morpholinyl]methyl]benzamide(112885-34-4)

Safety Data

• Hazardous Substances Data: 112885-34-4(Hazardous Substances Data)

Upstream product

• 22116-33-2 2-(4-fluoro-benzyl-amino)-ethanol 
• 112914-13-3 2-aminomethyl-4-(4-fluoro-benzyl) morpholine 
• 2486-67-1 4-acetylamino-2-ethoxy-benzoic acid ethyl ester 
• 459-57-4 4-fluorobenzaldehyde 
• 50-86-2 4-acetamidosalicylic acid 
• 133-10-8 sodium p-aminosalicylate 
• 112913-94-7 2-<(acetylamino)methyl>-4-(4-fluorobenzyl)morpholine 
• 112913-96-9 2-(N-acetylaminomethyl)-4-benzylmorpholine 
• 59-06-3 methyl 4-acetamido-2-ethoxybenzoate 

Downstream Products

• 112885-42-4 mosapride citrate 

Relevant articles and documents

Citric acid mosapride intermediate product and application

The invention belongs to the field of medical chemistry synthesis, and provides a preparation method of citric acid mosapride intermediate product IV 4-[(4-fluorophenyl)methyl]-2-morpholinemethanaminesalt and citric acid mosapride. The 2-(4-fluorobenzoamido)ethanol and 1H-Isoindole-1,3(2H)-dione,2-(2-oxiranylmethyl) are taken as raw materials, and the intermediate product IV 4-[(4-fluorophenyl)methyl]-2-morpholinemethanamine salt is obtained after acid treating is conducted; the intermediate product IV and an intermediate V 2-oxethyl-4-acetamido-5-Chlorobenzoic acid ethyl ester compounds aretaken as raw materials, dichloromethane is taken as a solvent, and EDCI and DMAP are taken as catalysts to prepare mosapride salt; the mosapride salt is reacted with citric acid aqueous solution to prepare citric acid mosapride. The intermediate product has the advantages that products are high in yield, raw materials are easy to obtain, the production cost is low, and the intermediate product issuitable for industrialized production.