112885-41-3 Usage
Description
Mosapride citrate, a new gastroprokinetic benzamide was introduced in
Japan as Gasmotin for the relief of gastrointestinal symptoms in patients with
chronic gastritis, gastro-oesophageal reflux, dyspepsia and post-surgery use.
Mosapride is synthesized by final amidation between the corresponding benzoic
acid, itself obtained in 3 steps from methyl 4-acetamido salicylate, and the
appropriate 2-aminomethyl-morpholine. Mosapride is a 5-HT4 partial agonist
without notable activity for D2, 5-HT1 , 5-HT2, alpha-1 and alpha-2 receptors. In
dogs, mosapride was as potent as cisapride to stimulate antral and duodenal
motility. In most of species including man, mosapride undergoes extensive
cleavage to a N-debenzylated metabolite which retains partial 5-HT4 activity but
has potent 5-HT3 antagonist activity.
Chemical Properties
White to Off-White Crystalline Solid
Originator
Dainippon (Japan)
Uses
Different sources of media describe the Uses of 112885-41-3 differently. You can refer to the following data:
1. A selective 5-HT4 receptor agonist. Gastroprokinetic.
2. gastroprokinetic agent
Brand name
Gasmotin
Hazard
A poison by ingestion.
Safety Profile
A poison by ingestion.
When heated to decomposition it emits
toxic vapors of NOx, F-, and Cl-.
Check Digit Verification of cas no
The CAS Registry Mumber 112885-41-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,2,8,8 and 5 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 112885-41:
(8*1)+(7*1)+(6*2)+(5*8)+(4*8)+(3*5)+(2*4)+(1*1)=123
123 % 10 = 3
So 112885-41-3 is a valid CAS Registry Number.
InChI:InChI=1/C21H25ClFN3O3/c1-2-28-20-10-19(24)18(22)9-17(20)21(27)25-11-16-13-26(7-8-29-16)12-14-3-5-15(23)6-4-14/h3-6,9-10,16H,2,7-8,11-13,24H2,1H3,(H,25,27)
112885-41-3Relevant articles and documents
Novel preparation method of mosapride
-
, (2021/08/07)
The invention discloses a novel preparation method of mosapride.Cheap 2-chlorotoluene is used as an initial raw material is subjected to nitration, nucleophilic substitution, free radical bromination, chlorination, alkylation, nitro reduction and oxidative amidation to synthesize mosapride. According to the scheme, raw materials are easy to obtain, dangerous processes and highly toxic reagents are avoided, the method is green and environment-friendly, oxidation amidation is adopted, selectivity is achieved, formation of aromatic amide by-products is avoided, and the yield is high.
4-amino-5-chloro-2-ethoxy-N- "[ 4-(4-Flurobenzyl)-2-morphorinyl] methyl" phenylbenzamide hydroxycitric salt 2 hydrate production method
-
Paragraph 0062-0064, (2016/10/08)
PROBLEM TO BE SOLVED: To provide a method for producing a high-purity 4-amino-5-chloro-2-ethoxy-N-[[4-(4-fluorobenzyl)-2-morpholinyl]methyl]benzamide citric acid salt dehydrate, which produces less by-product. SOLUTION: The method for producing a 4-amino-5-chloro-2-ethoxy-N-[[4-(4-fluorobenzyl)-2-morpholinyl]methyl]benzamide citric acid salt dehydrate includes reacting 4-amino-5-chloro-2-ethoxy-N-[[4-(4-fluorobenzyl)-2-morpholinyl]methyl]benzamide and citric acid at ≥30°C and ≤70°C in a mixed solvent of water and a water-soluble organic solvent. COPYRIGHT: (C)2012,JPOandINPIT
DRY-COATED ORALLY-DISINTEGRATING TABLET
-
, (2012/04/10)
The purpose of the present invention is to provide a press-coated orally-disintegrating tablet characterized by containing an inner core which has an excellent disintegratability in oral cavity and a suitable hardness as a whole tablet. The present invent
