1129-46-0Relevant articles and documents
Fourneau,Sandulesco
, (1923)
Improvement of catalytic activity of Candida rugosa lipase in the presence of calix[4]arene bearing iminodicarboxylic/phosphonic acid complexes modified iron oxide nanoparticles
Ozyilmaz, Elif,Bayrakci, Mevlut,Yilmaz, Mustafa
, p. 1 - 8 (2016)
In the present study, iron oxide magnetite nanoparticles, prepared through a co-precipitation method, were coated with phosphonic acid or iminodicarboxylic acid derivatives of calix[4]arene to modulate their surfaces with different acidic groups. Candida rugosa lipase was then directly immobilized onto the modified nanoparticles through sol-gel encapsulation. The catalytic activities and enantioselectivities of the two encapsulated lipases in the hydrolysis reaction of (R/S)-naproxen methyl ester and (R/S)-2-phenoxypropionic acid methyl ester were assessed. The results showed that the activity and enantioselectivity of the lipase were improved when the lipase was encapsulated in the presence of calixarene-based additives; the encapsulated lipase with the phosphonic acid derivative of calix[4]arene had an excellent rate of enantioselectivity against the (R/S)-naproxen methyl and (R/S)-2-phenoxypropionic acid methyl esters, with E = 350 and 246, respectively, compared to the free enzyme. The encapsulated lipases (Fe-Calix-N(COOH)) and (Fe-Calix-P) showed good loading ability and little loss of enzyme activity, and the stability of the catalyst was very good; they only lost 6-11% of the enzyme's activity after five batches.
Flash Chiral Chromatography using Carbohydrate Carbamate-coated Silica
Matlin, Stephen A.,Grieb, Sally J.,Belenguer, Ana M.
, p. 301 - 302 (1995)
Enantiomers of many chiral compounds are resolved rapidly on a preparative scale by passage through a column packed with flash chromatography silica which has been physically coated with a carbohydrate carbamate.
Parallel kinetic resolution of 2-methoxy and 2-phenoxy-substituted carboxylic acids using a combination of quasi-enantiomeric oxazolidinones
Boyd, Ewan,Chavda, Sameer,Eames, Jason,Yohannes, Yonas
, p. 476 - 482 (2007)
2-Methoxy-2-phenyl acetic acid and 2-phenoxy-2-phenylpropionic acid were resolved by the parallel kinetic resolution of their corresponding pentafluorophenyl active ester using a quasi-enantiomeric combination of lithiated oxazolidinones.
Preparation method of (R)-(+)-2-(4-hydroxyphenoxy) propionic acid
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Paragraph 0052-0053; 0055-0056; 0058-0059; 0061-0062, (2021/05/19)
The invention provides a preparation method of (R)-(+)-2-(4-hydroxyphenoxy) propionic acid, and belongs to the technical field of pesticide intermediate preparation. According to the method, phenol is used as a raw material, phenol and (S)-(-)-2-halogenated propionic acid react to synthesize R-(+)-2-phenoxypropionic acid, and (R)-(+)-2-(4-hydroxyphenoxy) propionic acid is obtained after oxidation. According to the invention, the raw material phenol used in the method is low in price, the procedure operation is simple, use of hydroquinone as the raw material is avoided, and the problems of high raw material cost, difficult product purification, low yield, low product quality and need of recovery of the raw material hydroquinone caused by hydroquinone disubstituted impurities generated in the reaction when hydroquinone is used as the raw material for synthesis in the traditional method are solved; and results of the embodiment show that the yield of the (R)-(+)-2-(4-hydroxyphenoxy) propionic acid prepared by the method is greater than 85%, the liquid phase content is greater than or equal to 99.5%, the optical purity e.e is greater than 99.0%, and the product is high in yield and good in quality.
Chemical synthesis method of (R)-2-phenoxypropionic acid
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Paragraph 0020; 0036; 0046; 0049; 0050, (2019/01/14)
The invention discloses a chemical synthesis method of (R)-2-phenoxypropionic acid. The chemical synthesis method comprises the following steps: performing diazotization and chlorination on L-alanineserving as a starting material to obtain (S)-2-chloropro