113059-25-9

Basic information

• Product Name: (phenyl)(2-phenylquinolin-3-yl)methanone
• Synonyms: (phenyl)(2-phenylquinolin-3-yl)methanone
• CAS NO: 113059-25-9
• Molecular Weight: 309.367
• Mol File: 113059-25-9.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: (phenyl)(2-phenylquinolin-3-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (phenyl)(2-phenylquinolin-3-yl)methanone(113059-25-9)
• EPA Substance Registry System: (phenyl)(2-phenylquinolin-3-yl)methanone(113059-25-9)

Safety Data

• Hazardous Substances Data: 113059-25-9(Hazardous Substances Data)

Upstream product

• 26260-02-6 2-iodobenzaldehyde 
• 98815-39-5 (Z)-3-amino-1,3-diphenylprop-2-en-1-one 
• 93098-67-0 diethyl <(2-bromophenyl)methylene>propanedioate 
• 1083-30-3 dihydrochalcone 
• 529-23-7 o-aminobenzaldehyde 
• 271-58-9 anthranil 
• 94-41-7 benzalacetophenone 
• 1621416-87-2 (Z)-1,3-diphenyl-3-{2-[(E)-(2-phenylethenyl)]phenylamino}prop-2-en-1-one 
• 27652-35-3 (E)-2-styrylaniline 
• 120-46-7 1,3-diphenylpropanedione 
• 6630-33-7 ortho-bromobenzaldehyde 
• 552-89-6 2-nitro-benzaldehyde 
• 29203-03-0 o-Nitrobenzylidendibenzoylmethan 
• 62961-62-0 (Z)-3-hydroxy-1,3-diphenyl-2-propen-1-one 

Downstream Products

• 612-96-4 2-Phenylquinoline 
• 65-85-0 benzoic acid 

Relevant articles and documents

Synthesis of quinolines: Via copper-catalyzed domino reactions of enaminones

Quinoline derivatives were obtained from enaminones and 2-bromo- or 2-iodobenzaldehydes via copper-catalyzed domino reactions consisting of the aldol reaction, C(aryl)-N bond formation and elimination. The electronic effect of aldehydes played a major role in the reaction outcome. Two simple protocols are disclosed to achieve various quinolines from both cyclic and acyclic enaminones in good yields. With the less-reactive acyclic enaminones, diethyl-2-(2-bromobenzylidene)malonate was shown to be more compatible than the benzaldehydes.

Ag(I)-promoted Decarboxylative Annulation of α-Oxocarboxylic Acids with (E)-3-(2-aminophenyl)-1-Phenylprop-2-en-1-ones Toward 3,4-Functionalized Quinolines

An efficient Ag-promoted decarboxylative cyclization of α-oxocarboxylic acids with (E)-3- (2-aminophenyl)-1-phenylprop-2-en-1-ones has been developed to afford a series of functionalized quinolines in moderate to good yields. This method was compatible with a variety of functional groups and provided an attractive method toward phenyl(2-phenylquinolin-3-yl)methanones.

NiH-Catalyzed Hydroamination/Cyclization Cascade: Rapid Access to Quinolines

Despite the significant success of metal-H-catalyzed hydroamination methodologies, considerable limitations still exist in the selective hydroamination of alkynes, especially for terminal alkynes. Herein, we develop a highly efficient NiH catalytic system that activates readily available alkynes for a cascade hydroamination/cyclization reaction with anthranils. This mild, operationally simple protocol is amenable to a wide array of alkynes including terminal and internal, aryl and alkyl, electron-deficient and electron-rich ones, delivering structurally diverse quinolines in useful to excellent yields (>80 examples, up to 93% yield). The utility of this procedure is exhibited in the late-stage functionalization of several natural products and in the concise synthesis of an antitumor molecule graveolinine and a triplex DNA intercalator. Preliminary mechanistic experiments suggest an alkenylnickel-mediated alkyne hydroamination and an intramolecular cyclization/aromatization of putative enamine intermediates.

Method for synthesizing quinoline derivatives

The invention discloses a method for synthesizing quinoline derivatives. 2,1-benzisoxazole derivatives represented by formula I and beta-diketone derivatives represented by formula II are used as rawmaterials, and are reacted to obtain the quinoline deriv