113326-75-3

Basic information

• Product Name: 4H-1-Benzopyran-4-one, 3-[(oxidophenylimino)methyl]-
• CAS NO: 113326-75-3
• Molecular Formula: C16H11NO3
• Molecular Weight: 265.268
• Mol File: 113326-75-3.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 4H-1-Benzopyran-4-one, 3-[(oxidophenylimino)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1-Benzopyran-4-one, 3-[(oxidophenylimino)methyl]-(113326-75-3)
• EPA Substance Registry System: 4H-1-Benzopyran-4-one, 3-[(oxidophenylimino)methyl]-(113326-75-3)

Safety Data

• Hazardous Substances Data: 113326-75-3(Hazardous Substances Data)

Upstream product

• 17422-74-1 3-Formylchromone 
• 100-65-2 N-Phenylhydroxylamine 
• 98-95-3 nitrobenzene 
• 118-93-4 o-hydroxyacetophenone 
• 122-79-2 Phenyl acetate 
• 108-95-2 phenol 

Downstream Products

• 113326-77-5 3-(2,5-Diphenyl-isoxazolidin-3-yl)-chromen-4-one 
• 113326-82-2 3-(2-Phenyl-5-p-tolyl-isoxazolidin-3-yl)-chromen-4-one 
• 113355-09-2 3-(4-Oxo-4H-chromen-3-yl)-2,5-diphenyl-tetrahydro-pyrrolo[3,4-d]isoxazole-4,6-dione 
• 113326-79-7 3-(4-Oxo-4H-chromen-3-yl)-2-phenyl-isoxazolidine-5-carbonitrile 
• 71592-11-5 (3Z)-3-[(phenylamino)methylidene]-3,4-dihydro-2H-1-benzopyran-2,4-dione 
• 71591-96-3 (3E)-3-[(phenylamino)methylidene]-3,4-dihydro-2H-1-benzopyran-2,4-dione 
• 213273-03-1 4-oxo-2-(N-phenyl)amino-4H-chromene-3-carbaldehyde 
• 33588-64-6 ethyl 2-(1H-indol-2-yl)acetate 

Relevant articles and documents

Intramolecular low-temperature 1,3-dipolar cycloadditions of nitrones: synthesis of chromano-heterocycles

In contrast to the reported facile intramolecular 1,3-dipolar cycloadditions of in-situ generated nitrone on heterocyclic systems, reactions of 2-(N-allyl/crotyl/cinnamyl-anilino)-3-formylchromones with N-phenyl-/methylhydroxylamine under comparable condi

Thermal rearrangements of C-(4-Oxo-4H[1]benzopyran-3-yl)-N- phenylnitrone-a route to novel quinolino[2,3-b] chroman-12-ones

C-(4-Oxo-4H[1]benzopyran-3-yl)-N-phenylnitrones (1a-c) undergo facile rearrangements on refluxing in benzene, yielding 2-(N-phenylamino)-4-oxo- 4H[1]-benzopyran-3-carboxaldehydes (2a-c,70%) and 3-(phenyliminomethylene)- chroman-2,4-diones (3a-c, 25%). 2a-

3-Formylchromone based topoisomerase IIα inhibitors: Discovery of potent leads

Substituted 3-formylchromones were synthesized and evaluated as inhibitors of the human DNA topoisomerase IIα (hTopo-IIα) enzyme. The results of the decatenation, relaxation and DNA intercalation assays revealed that the compounds (11b, 12a, 12b, 12d, 12e, 13a and 13b) exhibited potent inhibitory activity against the hTopo-IIα enzyme, and are nonintercalating agents. These compounds also possess significant in vitro cytotoxicity (LC50 ranges from 0.5-8.6 μM) against prostate (PC-3) cancerous cell line as seen in comparison to the standard drug etoposide. To further probe the plausible mode of action of 3-formylchromone derivatives, molecular docking studies have also been carried out, which showed that the compounds under investigation fitted well in the ATP binding pocket of hTopo-IIα enzyme with good docking scores and form nonbonding interactions with the crucial residues of the catalytic site. The Royal Society of Chemistry.

A one-pot rearrangement of 2-(N-Alkyl-N-aryl)aminochromone-3-carbaldehyde to N-Alkyl-3-salicyloyl-2-quinolone - An antileishmanial agent

2-(N-Aryl)aminochromone-3-carbaldehyde does not show any change on heating in acetic acid, but under the same reaction conditions 2-(N-alkyl-N-aryl) aminochromone-3-carbaldehyde rearranges to 3-salicyloyl-2-quinolones, which exhibits antileishmanial activ